Association between Plasma Sestrin2 Levels and the Presence and Severity of Coronary Artery Disease.
Yoshimi Kishimoto,Masayuki Aoyama,Emi Saita,Yukinori Ikegami,Reiko Ohmori,Kazuo Kondo,Kazuo Kondo,Yukihiko Momiyama +7 more
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Plasma sestrin2 levels in patients with CAD were found to be high and to be associated with the severity of CAD, which may reflect a protective response against the progression of CAD.Abstract:
Aims Atherosclerotic disease, such as coronary artery disease (CAD), is recognized to be associated with inflammation and oxidative stress. We investigated the association between CAD and plasma levels of sestrin2 which is one of the stress-inducible antioxidant proteins. Methods We measured plasma sestrin2 levels in 304 patients undergoing elective coronary angiography. The severity of CAD was represented as the numbers of >50% stenotic coronary vessels and segments and the severity score. Results CAD was found in 175 patients, of whom 73 had 1-vessel (1-VD), 59 had 2-vessel (2-VD), and 43 had 3-vessel disease (3-VD). Plasma sestrin2 levels were significantly higher in 175 patients with CAD than in 129 without CAD (median 16.4 vs. 14.2 ng/mL, P 50% stenotic coronary vessels: 14.2 in CAD(-), 15.4 in 1-VD, 17.3 in 2-VD, and 17.7 ng/mL in3-VD (P 16.0 ng/mL) was present in 38% of patients with CAD(-), 47% of 1-VD, 66% of 2-VD, and 53% of 3-VD (P 50% stenotic segments and the severity score (rs = 0.12 and rs = 0.13, P 16.0 ng/mL (P < 0.025). Conclusions Plasma sestrin2 levels in patients with CAD were found to be high and to be associated with the severity of CAD. High sestrin2 levels in patients with CAD may reflect a protective response against the progression of CAD.read more
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Sestrin 2, a potential star of antioxidant stress in cardiovascular diseases.
TL;DR: It is speculated that Sesn2 plays an important role in CVDs by stimulating the process of antioxidation and promoting the adaptation of cells to stress conditions and/or the environment, opening a new avenue for related therapeutic strategies.
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The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases
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