Journal ArticleDOI
Association of complement factor H Y402H gene polymorphism with different subtypes of exudative age-related macular degeneration.
B.J. Wegscheider,Martin Weger,Wilfried Renner,Iris Steinbrugger,Winfried März,Georg Mossböck,Werner Temmel,Yosuf El-Shabrawi,Otto Schmut,Renate Jahrbacher,Anton Haas +10 more
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TLDR
The data suggest that the CFH Y402H polymorphism is a major risk factor for exudative AMD in a Central European population of Caucasoid descent.About:
This article is published in Ophthalmology.The article was published on 2007-04-01. It has received 92 citations till now. The article focuses on the topics: Factor H & Gene polymorphism.read more
Citations
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Journal ArticleDOI
Do we need a new classification for choroidal neovascularization in age-related macular degeneration?
TL;DR: The introduction of intravitreal antivascular endothelial growth factor therapy for neovascular age-related macular degeneration (AMD) has not only improved the quality of life for patients but also raised the bar for what is considered effective treatment for this disease.
Journal ArticleDOI
Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab.
TL;DR: The AMD-associated CFH Y402H and LOC387715 A69S variants were associated with differences in choroidal neovascular lesion size in this study, suggesting a potential pharmacogenetic relationship.
Journal ArticleDOI
Ocular blood flow in diabetes and age-related macular degeneration
TL;DR: The 2 leading causes of blindness in adults in the industrialized nations, diabetic retinopathy and age-related macular degeneration, have been investigated thoroughly with respect to their pathogenesis and knowledge of the pathophysiological vascular states underlying these diseases is essential for the assessment and development of future therapies.
Journal ArticleDOI
Oxidative stress, innate immunity, and age-related macular degeneration.
TL;DR: The background literature surrounding the known genetic and environmental contributors to AMD risk are highlighted, as well as a discussion of the potential mechanistic interplay of these factors that lead to disease pathogenesis with particular emphasis on the delicate control of inflammatory homeostasis and the centrality of the innate immune system in this process.
Journal ArticleDOI
Age-related maculopathy - linking aetiology and pathophysiological changes to the ischaemia hypothesis.
TL;DR: In this article, a linking hypothesis between aetiological factors including ischaemia and genetics and the development of early clinicopathological changes in age-related maculopathy is proposed.
References
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Journal ArticleDOI
Complement Factor H Polymorphism in Age-Related Macular Degeneration
Robert J. Klein,Caroline J. Zeiss,Emily Y. Chew,Jen-yue Tsai,Richard S. Sackler,Chad Haynes,A. K. Henning,John Paul SanGiovanni,Shrikant Mane,Susan T. Mayne,Michael B. Bracken,Frederick L. Ferris,Jurg Ott,Colin J. Barnstable,Josephine Hoh +14 more
TL;DR: A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
Journal ArticleDOI
Complement factor H variant increases the risk of age-related macular degeneration.
Jonathan L. Haines,Michael A. Hauser,Silke Schmidt,William K. Scott,Lana M. Olson,Paul Gallins,Kylee L. Spencer,Shu Ying Kwan,Maher A. Noureddine,John R. Gilbert,Nathalie Schnetz-Boutaud,Anita Agarwal,Eric A. Postel,Margaret A. Pericak-Vance +13 more
TL;DR: DNA resequencing of the complement factor H gene within this haplotype revealed a common coding variant that significantly increases the risk for AMD with odds ratios between 2.45 and 5.57, which likely explains ∼43% of AMD in older adults.
Journal ArticleDOI
Complement Factor H Polymorphism and Age-Related Macular Degeneration
Albert O. Edwards,Robert C. Ritter,Kenneth Abel,Alisa K. Manning,Carolien I.M. Panhuysen,Lindsay A. Farrer +5 more
TL;DR: In this paper, single-nucleotide polymorphisms were tested for association with AMD in two independent case-control populations and significant association was identified within the regulation of complement activation locus and was centered over a tyrosine-402 --> histidine-402 protein polymorphism in the gene encoding complement factor.
Journal ArticleDOI
Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two-year results of 2 randomized clinical trials-tap report 2.
TL;DR: To report 24-month vision and fluorescein angiographic outcomes from trials evaluating photodynamic therapy with verteporfin (Visudyne) in patients with subfoveal choroidal neovascularization caused by age-related macular degeneration (AMD).
Journal ArticleDOI
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
Gregory S. Hageman,Don H. Anderson,Lincoln V. Johnson,Lisa S. Hancox,Andrew J Taiber,Lisa I. Hardisty,Jill L. Hageman,Heather Stockman,James D. Borchardt,Karen M. Gehrs,Richard J.H. Smith,Giuliana Silvestri,Stephen R. Russell,Caroline C W Klaver,Irene Barbazetto,Stanley Chang,Lawrence A. Yannuzzi,Gaetano R. Barile,John C. Merriam,R. Theodore Smith,Adam Olsh,Julie Bergeron,Jana Zernant,Joanna E. Merriam,Bert Gold,Michael Dean,Rando Allikmets +26 more
TL;DR: It is shown that factor H (HF1), the major inhibitor of the alternative complement pathway, accumulates within drusen and is synthesized by the retinal pigmented epithelium, implicating HF1 function in the pathogenetic mechanisms underlying AMD.
Related Papers (5)
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
Gregory S. Hageman,Don H. Anderson,Lincoln V. Johnson,Lisa S. Hancox,Andrew J Taiber,Lisa I. Hardisty,Jill L. Hageman,Heather Stockman,James D. Borchardt,Karen M. Gehrs,Richard J.H. Smith,Giuliana Silvestri,Stephen R. Russell,Caroline C W Klaver,Irene Barbazetto,Stanley Chang,Lawrence A. Yannuzzi,Gaetano R. Barile,John C. Merriam,R. Theodore Smith,Adam Olsh,Julie Bergeron,Jana Zernant,Joanna E. Merriam,Bert Gold,Michael Dean,Rando Allikmets +26 more