Association of Myocardial Enzyme Elevation and Survival Following Coronary Artery Bypass Graft Surgery
Michael J. Domanski,Kenneth W. Mahaffey,Vic Hasselblad,Sorin J. Brener,Peter K. Smith,Graham S. Hillis,Milo Engoren,John H. Alexander,Jerrold H. Levy,Bernard R. Chaitman,Samuel Broderick,Michael J. Mack,Karen S. Pieper,Michael E. Farkouh +13 more
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TLDR
To quantify the relationship between peak post-CABG elevation of biomarkers of myocardial damage and early, intermediate-, and long-term mortality, including determining whether there is a threshold below which elevations lack prognostic significance, a large number of patients undergoing CABG surgery were surveyed.Abstract:
confidenceinterval[CI],0.36%-1.02%)for0to1,0.86%(95%CI,0.49%-1.40%)for 1t o2, 0.95% (95% CI, 0.72%-1.22%) for 2 to 5, 2.09% (95% CI, 1.69%-2.57%) for5to10,2.78%(95%CI,2.12%-3.58%)for10to20,and7.06%(95%CI,5.46%8.96%) for 20 to 40. Of the variables considered, the CK-MB ratio was the strongest independent predictor of death to 30 days and remained significant even after adjusting for a wide range of baseline risk factors (read more
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Third universal definition of myocardial infarction
Kristian Thygesen,Joseph S. Alpert,Allan S. Jaffe,Maarten L. Simoons,Bernard R. Chaitman,Harvey D. White +5 more
TL;DR: Information on MI rates can provide useful information regarding the burden of CAD within and across populations, especially if standardized data are collected in a manner that …
The third universal definition of myocardial infarction
TL;DR: This article aims to provide a summary of this document along with its implications for nursing practice in different clinical situations.
Journal ArticleDOI
Third universal definition of myocardial infarction.
Kristian Thygesen,Joseph S. Alpert,Allan S. Jaffe,Maarten L. Simoons,Bernard R. Chaitman,Harvey D. White +5 more
TL;DR: The first manifestation of MI can be recognized by clinical features, including electrocardiographic (ECG) findings, elevated values of biochemical markers (biomarkers) of myocardial necrosis, and by imaging, or may be defined by pathology as mentioned in this paper.
Journal ArticleDOI
Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial
Matthias Thielmann,Eva Kottenberg,Petra Kleinbongard,Daniel Wendt,Nilgün Gedik,Susanne Pasa,Vivien Price,Konstantinos Tsagakis,Markus Neuhäuser,Jürgen Peters,Heinz Jakob,Gerd Heusch +11 more
TL;DR: Remote ischaemic preconditioning provided perioperative myocardial protection and improved the prognosis of patients undergoing elective CABG surgery.
Journal ArticleDOI
Consideration of a new definition of clinically relevant myocardial infarction after coronary revascularization: an expert consensus document from the Society for Cardiovascular Angiography and Interventions (SCAI).
Issam Moussa,Lloyd W. Klein,Binita Shah,Roxana Mehran,Michael J. Mack,Emmanouil S. Brilakis,John P. Reilly,Gilbert J. Zoghbi,Elizabeth Holper,Gregg W. Stone +9 more
TL;DR: A new definition for "clinically relevant MI" after coronary revascularization (PCI or CABG), which is applicable for use in clinical trials, patient care, and quality outcomes assessment is introduced.
References
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Journal ArticleDOI
The file drawer problem and tolerance for null results
TL;DR: Quantitative procedures for computing the tolerance for filed and future null results are reported and illustrated, and the implications are discussed.
Journal ArticleDOI
Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction.
Elliott M. Antman,Jean-Pierre Bassand,Werner Klein,Magnus Ohman,José Luis López Sendón,Lars Rydén,Maarten L. Simoons,Michal Tendera +7 more
TL;DR: In this paper, the authors defined the definition of MI and established the following criteria for acute, evolving or recent MI: 1) Typical rise and gradual fall (troponin) or more rapid rise and fall (CK-MB) of biochemical markers of myocardial necrosis with at least one of the following: a) ischemic symptoms; b) development of pathologic Qwaves on the ECG; c) ECG changes indicative of ischemia (ST segment elevation or depression); or d) coronary artery intervention (e.g., coronary ang
Journal ArticleDOI
Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
Joseph S. Alpert,Elliott M. Antman,Fred S. Apple,Paul W. Armstrong,J. P. Bassand,A. B. De Luna,George A. Beller,Günter Breithardt,Bernard R. Chaitman,Peter Clemmensen,Erling Falk,Michael C. Fishbein,Marcello Galvani,A Jr Garson,Cindy L. Grines,Christian W. Hamm,B. Nauheim,Uta C. Hoppe,Allan S. Jaffe,Hugo A. Katus,J. Kjeksus,Werner Klein,P. Klootwijk,C. Lenfant,Daniel Levy,R. I. Levy,Russell V. Luepker,F. Marcus,Ulf Näslund,Magnus Ohman,O. Pahlm,P. A. Poole-Wilson,R. Popp,Kalevi Pyörälä,Jan Ravkilde,N. Rehnquist,W. Roberts,Robert Roberts,J. Roelandt,Lars Rydén,Susana Sans,M. L. Simoons,Kristian Thygesen,Hugh Tunstall-Pedoe,Richard Underwood,Barry F. Uretsky,F. Van de Werf,L. M. Voipio-Pulkki,Galen S. Wagner,Lars Wallentin,William Wijns,David R. Wood +51 more
TL;DR: Biochemical markers of myocardial necrosis may have normalized, depending on the length of time that has passed since the infarct developed, and one of the following criteria satisfies the diagnosis for established MI: development of new pathologic Q waves on serial ECGs.
Journal ArticleDOI
Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial.
TL;DR: A phase 3 randomized, double-blind, placebo-controlled trial of 3014 patients undergoing primary CABG surgery with at least 2 planned saphenous vein grafts and without concomitant valve surgery found edifoligide is no more effective than placebo in preventing these events.
Journal ArticleDOI
Myonecrosis After Revascularization Procedures
Robert M. Califf,Alaa E. Abdelmeguid,Richard E. Kuntz,Jeffrey J. Popma,Charles J. Davidson,Eric A. Cohen,Neal S. Kleiman,Kenneth W. Mahaffey,Eric J. Topol,Carl J. Pepine,Ray J. Lipicky,Christopher B. Granger,Robert A. Harrington,Barbara E. Tardiff,Brian S. Crenshaw,Robert P. Bauman,Bram D. Zuckerman,Bernard R. Chaitman,John A. Bittl,E. Magnus Ohman +19 more
TL;DR: The detection of elevated cardiac enzyme levels and the occurrence of electrocardiographic (ECG) abnormalities after revascularization procedures have been the subject of recent controversy and this report represents an effort to achieve a consensus among a group of researchers with data on this subject.