Association of shorter leucocyte telomere length with risk of frailty
V. Bountziouka,Christopher P. Nelson,Veryan Codd,Qingning Wang,Crispin Musicha,Elias Allara,Stephen Kaptoge,Emanuele Di Angelantonio,Adam S. Butterworth,John F. Thompson,Elizabeth M Curtis,Angela M. Wood,John Danesh,Nicholas C. Harvey,Cyrus Cooper,Nilesh J. Samani +15 more
TLDR
Leucocyte telomere length (LTL), a proposed marker of biological age, has been associated with risk of many diseases and this work sought to determine whether LTL is associated withrisk of frailty.Abstract:
Frailty is a multidimensional syndrome of decline that affects multiple systems and predisposes to adverse health outcomes. Although chronological age is the major risk factor, inter‐individual variation in risk is not fully understood. Leucocyte telomere length (LTL), a proposed marker of biological age, has been associated with risk of many diseases. We sought to determine whether LTL is associated with risk of frailty.read more
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Association of shorter leucocyte telomere length with risk of frailty
V. Bountziouka,Christopher P. Nelson,Veryan Codd,Qingning Wang,Crispin Musicha,Elias Allara,Stephen Kaptoge,Emanuele Di Angelantonio,Adam S. Butterworth,John F. Thompson,Elizabeth M Curtis,Angela M. Wood,John Danesh,Nicholas C. Harvey,Cyrus Cooper,Nilesh J. Samani +15 more
TL;DR: Leucocyte telomere length (LTL), a proposed marker of biological age, has been associated with risk of many diseases and this work sought to determine whether LTL is associated withrisk of frailty.
Journal ArticleDOI
Associations between leukocyte telomere length and osteosarcopenia in 20,400 adults aged 60 years and over: Data from the UK Biobank.
TL;DR: In this article , the authors examined the association between leukocyte telomere length and osteosarcopenia using older adults aged 60 years and over in the UK Biobank.
Journal ArticleDOI
Associations between Frailty and Ambient Temperature in Winter: Findings from a Population-Based Study
TL;DR: Wang et al. as discussed by the authors investigated the associations between frailty and ambient temperature in winter among older adults and found that lower levels of ambient temperature was associated with higher likelihood of prefrailty and frailty.
Journal ArticleDOI
Telomere Length of Peripheral Blood Mononuclear Cells is Associated with Discharge Disposition in Older Trauma Patients
TL;DR: In this paper , the role of peripheral blood mononuclear cell telomere length (PBMC-TL) and response to traumatic injury was investigated in the context of coagulation and clinical outcomes after injury.
Journal ArticleDOI
Telomere length of peripheral blood mononuclear cells is associated with discharge disposition in older trauma patients
Julie Goswami,Taleen A. MacArthur,Dhanya Ramachandran,Cillian Mahony,Annelise Howick,Tammy Price-Troska,Riley J Thompson,Grant M. Spears,Kent R. Bailey,Mrinal M. Patnaik,João F. Passos,Myung Soon Park,Alejandro Ferrer +12 more
TL;DR: In this paper , the role of peripheral blood mononuclear cell telomere length (PBMC-TL) and response to traumatic injury was investigated in the context of coagulation and clinical outcomes after injury.
References
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Journal ArticleDOI
Frailty in Older Adults Evidence for a Phenotype
Linda P. Fried,Catherine M. Tangen,Jeremy D. Walston,Anne B. Newman,Calvin H. Hirsch,John S. Gottdiener,Teresa E. Seeman,Russell P. Tracy,Willem J. Kop,B Gregory Burke,Mary Ann McBurnie +10 more
TL;DR: This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
Journal ArticleDOI
A global clinical measure of fitness and frailty in elderly people
Kenneth Rockwood,Xiaowei Song,Chris MacKnight,Howard Bergman,David B. Hogan,Ian McDowell,Arnold Mitnitski +6 more
TL;DR: The ability of the Clinical Frailty Scale to predict death or need for institutional care, and correlated the results with those obtained from other established tools are determined.
Journal ArticleDOI
Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study
TL;DR: The findings challenge the single-disease framework by which most health care, medical research, and medical education is configured, and a complementary strategy is needed, supporting generalist clinicians to provide personalised, comprehensive continuity of care, especially in socioeconomically deprived areas.
Journal ArticleDOI
Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and Care
TL;DR: A narrative review of current understanding of the definitions and distinguishing characteristics of each of these conditions, including their clinical relevance and distinct prevention and therapeutic issues, and how they are related is provided.
Journal ArticleDOI
Frailty Consensus: A Call to Action
John E. Morley,Bruno Vellas,G. Abellan Van Kan,Stefan D. Anker,Juergen M. Bauer,Roberto Bernabei,Matteo Cesari,Wm. Cameron Chumlea,Wolfram Doehner,Jonathan Evans,Linda P. Fried,Jack M. Guralnik,Paul R. Katz,Theodore K. Malmstrom,Roger McCarter,Luis Miguel Francisco Gutierrez Robledo,Kenneth Rockwood,Stephan von Haehling,Maurits Vandewoude,Jeremy D. Walston +19 more
TL;DR: For the purposes of optimally managing individuals with physical frailty, all persons older than 70 years and all individuals with significant weight loss (>5%) due to chronic disease should be screened for frailty.