Associations between two single nucleotide polymorphisms of adiponectin gene and coronary artery diseases.
Chan-Hee Jung,Eun-Jung Rhee,Se-Yeon Kim,Hun-Sub Shin,Byung Jin Kim,Ki Chul Sung,Bum-Su Kim,Won Young Lee,Jin Ho Kang,Ki-Won Oh,Man-Ho Lee,Sun Woo Kim,Jung-Roe Park +12 more
TLDR
This study showed that SNP +276G>T and +45T>G in adiponectin gene were not associated with the presence of CAD, and no significant association was observed between the severity of CAD and either SNPs.Abstract:
Adiponectin, an adipocyte-secreted protein, is known to have anti-atherogenic, anti-inflammatory and anti-diabetic properties and its serum levels are decreased in obesity, type 2 diabetes, and coronary artery disease. Several studies have been performed to investigate the association of genetic variations in the adiponectin with obesity, insulin resistance, and type 2 diabetes, but few studies were performed in association with coronary artery disease. Therefore we examined the associations between two single nucleotide polymorphisms (SNPs), +45T>G and +276G>T of the adiponectin gene, and coronary artery diseases (CAD). One hundred and fifty six subjects (mean age 57.4 yrs) were enrolled in which coronary angiograms were performed due to chest pain. Genotypings were done for two SNPs in the adiponectin gene by Taqman polymerase chain reaction (PCR) method. The presence of CAD was defined as a >50% reduction of coronary artery diameter. Among 156 subjects, the allele frequencies were 0.683 for G allele and 0.317 for T allele in SNP +276G>T and 0.705 for T allele and 0.295 for G allele in SNP +45T>G. Both genotypes were in compliance with Hardy-Weinberg equilibrium. No association with the presence of CAD was observed for adiponectin gene SNP276 and SNP45 (p = 0.954, p = 0.843). Also, no significant association was observed between the severity of CAD and either SNPs (p = 0.571, p = 0.955). Our study showed that SNP +276G>T and +45T>G in adiponectin gene were not associated with the presence of CAD. Further studies will be necessary to confirm the role of SNP 276G>T and 45T>G in the development of CAD.read more
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Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects
Sheila K Patel,Allan Flyvbjerg,Michaela Kozakova,Jan Frystyk,Ibrahim Ibrahim,John R. Petrie,Peter Avery,Ele Ferrannini,Mark Walker +8 more
TL;DR: Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels.
Journal ArticleDOI
Association between polymorphisms in the adiponectin gene and cardiovascular disease: a meta-analysis.
TL;DR: The present meta-analysis showed that the associations between rs2241766, rs1501299 and rs266729 in the ADIPOQ and CVD were significant but weak, and high quality studies are still needed to confirm the associations.
Journal ArticleDOI
Association of ADIPOQ gene polymorphisms and coronary artery disease risk: A meta-analysis based on 12 465 subjects
TL;DR: Different SNPs of the ADIPOQ gene have different associations with CAD risk, and appear to increase risk in individuals of Asian ethnicity while decrease the CAD risk in Caucasians, however, the overall strength of association was mild to moderate.
Journal ArticleDOI
Obesity-associated genetic variants in young Asian Indians with the metabolic syndrome and myocardial infarction.
TL;DR: The metabolic syndrome occurs commonly in young Asian Indian patients with acute myocardial infarction and no relationship was found between any obesity-associated polymorphism and the metabolic syndrome.
Journal ArticleDOI
Single nucleotide polymorphism rs3774261 in the AdipoQ gene is associated with the risk of coronary heart disease (CHD) in Northeast Han Chinese population: a case-control study.
Joseph Sam Kanu,Yulu Gu,Sun Zhi,Mingxi Yu,Yuping Lu,Yetong Cong,Yunkai Liu,Yong Li,Yaqin Yu,Yi Cheng,Yawen Liu +10 more
TL;DR: Variations in AdipoQ gene can protect against CHD or be associated with CHD risk or associated withCHD risk in Northeast Han Chinese – findings that will help shed light on the reported conflicting roles of AdIPoQ in cardiovascular diseases are found.
References
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Kikuko Hotta,Tohru Funahashi,Yukio Arita,Masahiko Takahashi,Morihiro Matsuda,Yoshihisa Okamoto,Hiromi Iwahashi,Hiroshi Kuriyama,Noriyuki Ouchi,Kazuhisa Maeda,Makoto Nishida,Shinji Kihara,Naohiko Sakai,Tadahisa Nakajima,Kyoichi Hasegawa,Masahiro Muraguchi,Yasukazu Ohmoto,Tadashi Nakamura,Shizuya Yamashita,Toshiaki Hanafusa,Yuji Matsuzawa +20 more
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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
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Novel Modulator for Endothelial Adhesion Molecules: Adipocyte-Derived Plasma Protein Adiponectin
Noriyuki Ouchi,Shinji Kihara,Yukio Arita,Kazuhisa Maeda,Hiroshi Kuriyama,Yoshihisa Okamoto,Kikuko Hotta,Makoto Nishida,Masahiko Takahashi,Tadashi Nakamura,Shizuya Yamashita,Tohru Funahashi,Yuji Matsuzawa +12 more
TL;DR: Observations suggest that adiponectin modulates endothelial inflammatory response and that the measurement of plasma adiponECTin levels may be helpful in assessment of CAD risk.