Astrocytes: Orchestrating synaptic plasticity?
TLDR
Evidence is reviewed and discussed that pinpoints to a possible non-neuronal, glial candidate for such orchestration: the regulation of synaptic plasticity by astrocytes.About:
This article is published in Neuroscience.The article was published on 2016-05-26 and is currently open access. It has received 206 citations till now. The article focuses on the topics: Metaplasticity & Synaptic scaling.read more
Citations
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Physiology of astroglia
TL;DR: Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
Supporting Online Material for Astrocytes Potentiate Transmitter Release at Single Hippocampal Synapses
Gertrudis Perea,Alfonso Araque +1 more
TL;DR: Results indicate that astrocytes are actively involved in the transfer and storage of synaptic information and mGluR-mediated but N-methyl-d-aspartate receptor–independent plasticity is observed.
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Direct current stimulation modulates LTP and LTD: activity dependence and dendritic effects
TL;DR: The results highlight the role of DCS as a modulator, rather than inducer of synaptic plasticity, as well as the dependence ofDCS effects on the spatial and temporal properties of endogenous synaptic activity.
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Diversity and Specificity of Astrocyte-neuron Communication.
Caitlin A. Durkee,Alfonso Araque +1 more
TL;DR: Diversity and complexity of astrocyte-synapse interactions greatly enhance the degrees of freedom of the neural circuits and the consequent computational power of the Neural systems.
References
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The Organization of Behavior: A Neuropsychological Theory
TL;DR: In this paper, the authors discuss the first stage of perception: growth of the assembly, the phase sequence, and the problem of Motivational Drift, which is the line of attack.
Journal ArticleDOI
Short-Term Synaptic Plasticity
Robert S. Zucker,Wade G. Regehr +1 more
TL;DR: The evidence for this hypothesis, and the origins of the different kinetic phases of synaptic enhancement, as well as the interpretation of statistical changes in transmitter release and roles played by other factors such as alterations in presynaptic Ca(2+) influx or postsynaptic levels of [Ca(2+)]i are discussed.
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Robert C. Malenka,Mark F. Bear +1 more
TL;DR: This work reviews those forms of LTP and LTD for which mechanisms have been most firmly established and examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function.
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Peter Dayan,L. F. Abbott +1 more
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