Author response: New tools for automated high-resolution cryo-EM structure determination in RELION-3
Jasenko Zivanov,Takanori Nakane,Björn O. Forsberg,Dari Kimanius,Wim J. H. Hagen,Erik Lindahl,Erik Lindahl,Sjors H.W. Scheres +7 more
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This article is published in eLife.The article was published on 2018-11-05 and is currently open access. It has received 1038 citations till now.read more
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BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Yunlong Cao,Ayijiang Yisimayi,F. Jian,Weiliang Song,T. Xiao,Lei Wang,Shuo Du,Qianqian Li,Xiao-song Chen,Yuanling Yu,Peng Wang,Zhiying Zhang,Pulan Liu,Ran An,Xiaohua Hao,Yao Wang,Jing Wang,Rui Feng,Haiyan Sun,Li-Jin Zhao,Wen Zhang,Dong Zhao,Jiang Zheng,Lingling Yu,Can Li,Na Zhang,Rui Wang,Xiaowei Niu,Siyuan Yang,Xuetao Song,Yangyang Chai,Ye Hu,Yansong Shi,Lin-Sheng Zheng,Zhiqiang Li,Qingqing Gu,Fei Shao,Weijin Huang,Ronghua Jin,Zhong-yang Shen,Youchun Wang,Xiangxi Wang,Junyu Xiao,Xiaoliang Sunney Xie +43 more
TL;DR: In this paper , the authors show that BA.4/BA.5 exhibit higher transmissibility than BA.2.1, BA.12.1 and BA.1.
Posted ContentDOI
Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein
Alexandra C. Walls,Young-Jun Park,M. Alejandra Tortorici,M. Alejandra Tortorici,Abigail Wall,Andrew T. McGuire,Andrew T. McGuire,David Veesler +7 more
TL;DR: It is demonstrated that SARS-CoV-2 S mediates entry in VeroE6 cells and in BHK cells transiently transfected with human ACE2, establishing ACE2 as a functional receptor for this novel coronavirus and indicating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination.
Journal ArticleDOI
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2
Pengcheng Han,Lin-jie Li,Sheng Liu,Qisheng Wang,Di Zhang,Zepeng Xu,Pu Han,Xiaomei Li,Qi Peng,Chao Su,Baihan Huang,Dedong Li,Rong Zhang,M. Tian,Lutang Fu,Yuanzhu Gao,Xin Zhao,Kefang Liu,Jianxun Qi,George F. Gao,Peiyi Wang +20 more
TL;DR: In this article , the binding properties between the human receptor ACE2 (hACE2) and the VOC RBDs were studied and the crystal and cryoelectron microscopy structures of the omicron RBD-hACE 2 complex were resolved.
Journal ArticleDOI
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
Zhen Cui,Pan Liu,Nianshuang Wang,Lei Wang,Kaiyue Fan,Qianhui Zhu,Kang-Sheng Wang,Ruihong Chen,Rui Feng,Zijing Jia,Minnan Yang,Ge Xu,Boling Zhu,Wangjun Fu,Tian-jiang Chu,Lei Feng,Yide Wang,Xin-Guo Pei,Peng-Yu Yang,Xiaoliang Sunney Xie,Lei Cao,Yunlong Cao,Xiangxi Wang +22 more
TL;DR: In this article , the structure of the spike (S) from Omicron reveals amino acid substitutions forging interactions that stably maintain an active conformation for receptor recognition, which can be used for the development of broad-spectrum vaccines and therapeutics.
Posted ContentDOI
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
Cong Xu,Cong Xu,Yanxing Wang,Caixuan Liu,Caixuan Liu,Chao Zhang,W. Han,W. Han,Xiaoyu Hong,Xiaoyu Hong,Yifan Wang,Yifan Wang,Qin Hong,Qin Hong,S. Wang,S. Wang,Qiaoyu Zhao,Qiaoyu Zhao,Yalei Wang,Yong Yang,Kaijian Chen,Kaijian Chen,Wei Zheng,Wei Zheng,Liangliang Kong,Fangfang Wang,Qinyu Zuo,Zhong Huang,Yao Cong,Yao Cong +29 more
TL;DR: These findings offer a thorough picture on the mechanism of ACE2-induced conformational transitions of S-trimer from ground prefusion state towards postfusion state, thereby providing important information for development of vaccines and therapeutics aimed to block receptor binding.
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