Journal ArticleDOI
Barrier properties of mucus.
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TLDR
The physiological and biochemical properties that form the mucus barrier are reviewed, including shear-thinning, which makes it an excellent lubricant that ensures an unstirred layer of mucus remains adherent to the epithelial surface.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2009-02-27. It has received 1169 citations till now. The article focuses on the topics: Mucus.read more
Citations
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PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
TL;DR: The history of the development of PEGylated nanoparticle formulations for systemic administration is described, including how factors such as PEG molecular weight, PEG surface density, nanoparticle core properties, and repeated administration impact circulation time.
Journal ArticleDOI
Engineering precision nanoparticles for drug delivery
Michael J. Mitchell,Margaret M. Billingsley,Rebecca M Haley,Marissa E. Wechsler,Nicholas A. Peppas,Robert Langer +5 more
TL;DR: Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.
Journal ArticleDOI
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
TL;DR: The tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles are described and the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms are reviewed to provide targeted or sustained drug delivery for localized therapies in mucosal tissues.
Journal ArticleDOI
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
TL;DR: The protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier are addressed.
Journal ArticleDOI
Airway mucus function and dysfunction.
John V. Fahy,Burton F. Dickey +1 more
TL;DR: Pulmonary defense against environmental injury depends on airway mucus, which traps inhaled toxins that are then cleared from the lungs by ciliary beating and cough.
References
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Journal ArticleDOI
Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
Book
Physiology of the Gastrointestinal Tract
TL;DR: Physiology of the Gastrointestinal Tract, Fifth Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.
Journal ArticleDOI
Epithelial Mucin Genes
TL;DR: Functional studies are in progress both in vitro using cDNAs and cell lines and in vivo utilizing mutant mice in which a particular mucin gene has been inactivated or overexpressed to help determine whether the functions of mucins are restricted to protection and lubrication, or if they are involved in the adhesion of tumor cells to other cells or tissue components or in modulation of the immune system.
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Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Samuel K. Lai,D. Elizabeth O'Hanlon,Suzanne Harrold,Stan T. Man,Ying Ying Wang,Richard A. Cone,Justin Hanes +6 more
TL;DR: It is demonstrated that large nanoparticles, if properly coated, can rapidly penetrate physiological human mucus, and they offer the prospect thatLarge nanoparticles can be used for mucosal drug delivery.
Journal ArticleDOI
Lubrication by charged polymers
TL;DR: It is shown that brushes of charged polymers (polyelectrolytes) attached to surfaces rubbing across an aqueous medium result in superior lubrication compared to other polymeric surfactants.