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Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341) as discussed by the authors proposed a new method for the development of infants.Abstract:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341)read more
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Corticostriatal connectivity and its role in disease
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Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits.
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Neurobiology of rodent self-grooming and its value for translational neuroscience.
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References
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Subdivisions of the dopamine-containing A8-A9-A10 complex identified by their differential mesostriatal innervation of striosomes and extrastriosomal matrix.
TL;DR: Different subdivisions of the A8-A9-A10 dopamine-containing cell complex of the cat's mesencephalon project preferentially to striosomes or to extrastriosomal matrix, including a channel providing dopaminergic modulation of sensorimotor processing in the striatal matrix and, from the densocellular zone of the substantia nigra pars compacta, a channel leading to limbic-related mechanisms represented in the stripping system.
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Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors.
Jenny E. Westin,Linda Vercammen,Linda Vercammen,Elissa M. Strome,Christine Konradi,M. Angela Cenci +5 more
TL;DR: L-DOPA produces pronounced activation of ERK1/2 signaling in the dopamine-denervated striatum through a D1-receptor-dependent mechanism, which is associated with the development of dyskinesia.
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Correspondence between the dopamine islands and striosomes of the mammalian striatum.
TL;DR: A correspondence between the dopamine islands and striosomes is established and it is demonstrated that the acetylcholinesterase-rich patches of the immature caudate nucleus become the acetycholine hydroxylase-poor striosome of the adult.
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Neostriatal cell subtypes and their functional roles.
TL;DR: How spiny and aspiny striatal cells have been shown to be heterogeneous in their physiological, chemical and connection characteristics and how these cell subtypes are organized in the local circuitry of the striatum and their physiological roles in the basal ganglia are discussed are discussed.
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Transcriptional signatures in Huntington's disease.
TL;DR: Gene expression studies have been applied to human HD, thus not only validating the approach of using model systems, but also solidifying the idea that altered transcription is a key mechanism in HD pathogenesis.