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Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341) as discussed by the authors proposed a new method for the development of infants.Abstract:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341)read more
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Journal ArticleDOI
Stereotyped, automatized and habitual behaviours: are they similar constructs under the control of the same cerebral areas?
TL;DR: The basal ganglia capability in executing ordered motor patterns in which any single movement is linked to each other into an action, and many actions are ordered into each other, giving them a syntactic value to the final behaviour.
Journal ArticleDOI
Gilles-de-la-Tourette-Syndrom als Modell für eine Hirnentwicklungsstörung: Altersabhängige Strukturauffälligkeiten
Valerie Brandt,Christos Ganos +1 more
TL;DR: In this article, an Übersicht konzentriert sich auf strukturellen Unterschieden des Gehirns zwischen Gilles-de-la-Tourette-Syndrom (GTS) patients and gesunden Kontrollprobanden.
Book ChapterDOI
Chapter 9 – Role of D2-like Heteroreceptor Complexes in the Effects of Cocaine, Morphine, and Hallucinogens
Dasiel O. Borroto-Escuela,Karolina Wydra,Luca Ferraro,Alicia Rivera,Małgorzata Filip,Małgorzata Filip,Kjell Fuxe +6 more
TL;DR: Novel insights are given into the molecular mechanism for the therapeutic actions of atypical antipsychotic drugs with a high affinity for the 5-HT 2A R receptors.
Dissertation
Estudo do papel dos neurônios dopaminérgicos da substância negra no condicionamento de lugar com sacarose e quinino
TL;DR: The data show that the partial loss of dopamine neurons in the SNc impairs aversive associative learning, but not the appetitive learning, which has important implications in basic and applied research of Parkinson's disease, addiction, learning and memory, and other conditions where striatal DA is implicated.
Book ChapterDOI
Pathophysiology of Dystonia: Models and Mechanisms
TL;DR: The degree to which changes in firing rates/patterns and broadened receptive fields in these circuits contribute to the manifestation of dystonia is unclear but may be secondary to the development of uncontrolled temporal-spatial changes in synchronization and underlying changes in neuro-plasticity within these circuits.
References
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Journal ArticleDOI
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex
TL;DR: The basal ganglia serve primarily to integrate diverse inputs from the entire cerebral cortex and to "funnel" these influences, via the ventrolateral thalamus, to the motor cortex.
Journal Article
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
Manish A. Shah,Nicole A. Datson,Lakshmi Srinidhi,Vincent P. Stanton,Marcy E. MacDonald,Marc W. Allard,S. Youngman,Anna-Maria Frischauf,Richard Mott,KM Draths,Günther Zehetner,C. O’Donovan,Thomas J. Fielder,Bruce G. Jenkins,Manju Swaroop,Sherryl A.M. Taylor,Lynn Doucette-Stamm,Heather MacFarlane,Scott A. Strobel,H. E. McFarlane,Alan Buckler,Nicolet Groot,Holger Hummerich,Deanna M. Church,M. A. Anderson,Marianne James,Glenn Barnes,M. Christine,Francis S. Collins,Mabel P. Duyao,Peter B. Dervan,Gillian P. Bates,T Holloway,Peter S. Harper,TW Mcdonald,M North,K Blanchard,John J. Wasmuth,D. Shaw,Hans Lehrach,Danilo A. Tagle,Annemarie Poustka,David E. Housman,T. Huntington,Zdenek Sedlacek,Laura Riba,Susan F. Kirby,Carol Lin,Richard H. Myers,Leslie M. Thompson,Russell G. Snell,Michael Conlon O'Donovan,K Gillespie,Rita Shiang,Nancy S. Wexler,Christine Ambrose,J. F. Gusella,Sarah Baxendale,N. Groat,John Valdes +59 more
TL;DR: The Huntington's disease mutation involves an unstable DNA segment, similar to those described in fragile X syndrome, spino-bulbar muscular atrophy, and myotonic dystrophy, acting in the context of a novel 4p16.3 gene to produce a dominant phenotype.
Journal ArticleDOI
The functional anatomy of basal ganglia disorders.
TL;DR: A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control.
Journal ArticleDOI
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
TL;DR: The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis as mentioned in this paper.
Book
The Cognitive Neurosciences
TL;DR: The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition -the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind as discussed by the authors.