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Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341) as discussed by the authors proposed a new method for the development of infants.Abstract:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341)read more
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Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model.
Helen N. Schwerdt,Helen N. Schwerdt,Elizabeth Zhang,Elizabeth Zhang,Min Jung Kim,Tomoko Yoshida,Lauren L. Stanwicks,Satoko Amemori,Huseyin E Dagdeviren,Robert Langer,Michael J. Cima,Ann M. Graybiel +11 more
TL;DR: These findings demonstrate that monitoring of chemical activity patterns in the brain over at least year-long periods, long a goal of both basic and clinical neuroscience, is achievable.
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Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization
Sean Michael Kelly,Sean Michael Kelly,Ricardo Raudales,Ricardo Raudales,Miao He,Jannifer H. Lee,Yongsoo Kim,Leif G. Gibb,Priscilla Wu,Katherine Matho,Pavel Osten,Ann M. Graybiel,Z. Josh Huang +12 more
TL;DR: Through genetic fate mapping, it is demonstrated that striosome-matrix compartmentalization arises from a lineage program embedded in lateral ganglionic eminence radial glial progenitors mediating neurogenesis through two distinct types of intermediate progenitor (IPs).
Journal ArticleDOI
Chronic MPTP administration regimen in monkeys: a model of dopaminergic and non-dopaminergic cell loss in Parkinson's disease.
TL;DR: It is argued that long-term chronic administration of MPTP leads to brain pathology beyond the dopaminergic system that displays close similarities to that seen in PD patients and suggests that the chronically MPTP-treated nonhuman primate model may be suitable to study the pathophysiology and therapeutics of some non-motor features of PD.
Journal ArticleDOI
Retinoic Acid Receptor β Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms.
Monika Rataj-Baniowska,Anna Niewiadomska-Cimicka,Marie Paschaki,Monika Szyszka-Niagolov,Laura Carramolino,Miguel Torres,Pascal Dollé,Wojciech Krezel +7 more
TL;DR: It is shown that retinoic acid receptor β (RARβ) controls development of a subpopulation of GABAergic, Gad65-positive striatonigral projection neurons, which constitute one of the two major output pathways of the striatum.
Journal ArticleDOI
The role of the dorsal striatum in choice impulsivity.
TL;DR: The converging evidence for the associations of choice impulsivity with the reward valuation coded by the caudate, a ventral‐to‐dorsal gradient in the dorsal striatum, the origins of striatal afferents, and developmental maturation of frontostriatal connectivity during adolescence are discussed.
References
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Journal ArticleDOI
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex
TL;DR: The basal ganglia serve primarily to integrate diverse inputs from the entire cerebral cortex and to "funnel" these influences, via the ventrolateral thalamus, to the motor cortex.
Journal Article
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
Manish A. Shah,Nicole A. Datson,Lakshmi Srinidhi,Vincent P. Stanton,Marcy E. MacDonald,Marc W. Allard,S. Youngman,Anna-Maria Frischauf,Richard Mott,KM Draths,Günther Zehetner,C. O’Donovan,Thomas J. Fielder,Bruce G. Jenkins,Manju Swaroop,Sherryl A.M. Taylor,Lynn Doucette-Stamm,Heather MacFarlane,Scott A. Strobel,H. E. McFarlane,Alan Buckler,Nicolet Groot,Holger Hummerich,Deanna M. Church,M. A. Anderson,Marianne James,Glenn Barnes,M. Christine,Francis S. Collins,Mabel P. Duyao,Peter B. Dervan,Gillian P. Bates,T Holloway,Peter S. Harper,TW Mcdonald,M North,K Blanchard,John J. Wasmuth,D. Shaw,Hans Lehrach,Danilo A. Tagle,Annemarie Poustka,David E. Housman,T. Huntington,Zdenek Sedlacek,Laura Riba,Susan F. Kirby,Carol Lin,Richard H. Myers,Leslie M. Thompson,Russell G. Snell,Michael Conlon O'Donovan,K Gillespie,Rita Shiang,Nancy S. Wexler,Christine Ambrose,J. F. Gusella,Sarah Baxendale,N. Groat,John Valdes +59 more
TL;DR: The Huntington's disease mutation involves an unstable DNA segment, similar to those described in fragile X syndrome, spino-bulbar muscular atrophy, and myotonic dystrophy, acting in the context of a novel 4p16.3 gene to produce a dominant phenotype.
Journal ArticleDOI
The functional anatomy of basal ganglia disorders.
TL;DR: A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control.
Journal ArticleDOI
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
TL;DR: The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis as mentioned in this paper.
Book
The Cognitive Neurosciences
TL;DR: The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition -the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind as discussed by the authors.