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Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341) as discussed by the authors proposed a new method for the development of infants.Abstract:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341)read more
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Repeated methamphetamine administration differentially alters fos expression in caudate-putamen patch and matrix compartments and nucleus accumbens
TL;DR: Investigation of the effects of pretreatment with methamphetamine on the ability of a subsequent methamphetamine challenge to induce Fos protein expression in the patch and matrix compartments of the dorsolateral and dorsomedial caudate-putamen and in the ventral striatum suggests that drug-induced alterations in the patches compartment of the dorsal caudates may preferentially contribute to some of the enduring changes in brain activity and behavior produced by repeated treatment with methamphetamine.
Journal ArticleDOI
Increased insula-putamen connectivity in X-linked dystonia-parkinsonism.
Anne J. Blood,Jeff L. Waugh,Thomas F. Münte,Marcus Heldmann,Aloysius Domingo,Christine Klein,Hans C. Breiter,Lillian V. Lee,Raymond L. Rosales,Norbert Brüggemann +9 more
TL;DR: Relative connectivity of paralimbic versus sensorimotor cortex with the caudate and putamen in 17 individuals with XDP and 17 matched controls was evaluated, suggesting insula and/or parALimbic connectivity in XDP may develop abnormally and/ or increase in the years before symptom onset.
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Synaptic Dysfunction in Huntington's Disease: Lessons from Genetic Animal Models.
Carlos Cepeda,Michael Levine +1 more
TL;DR: A more complete picture of synaptic dysfunction in the cortico-basal ganglia-cortical loop is emerging and some therapeutic avenues aimed at rescuing synaptic dysfunction are highlighted.
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Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia
Hannah Hamburg,Hannah Hamburg,Svenja V. Trossbach,Verian Bader,Caroline Chwiesko,Anja Kipar,Magdelena Sauvage,William R. Crum,Anthony C. Vernon,Hans-Jürgen Bidmon,Carsten Korth +10 more
TL;DR: The anatomical investigation of a defined model for sporadic mental illness enables a clearer definition of neuroanatomical changes associated with subsets of human sporadic schizophrenia and demonstrates how a single molecular factor, DISC1 overexpression or misassembly, can account for a variety of seemingly unrelated morphological phenotypes.
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Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role.
Hidetaka Koizumi,Ryoma Morigaki,Shinya Okita,Shinji Nagahiro,Ryuji Kaji,Masanori Nakagawa,Satoshi Goto +6 more
TL;DR: A potent compensatory role of striosomal opioid signaling under the conditions of the striatal dopamine depletion that occurs in Parkinson's disease is proposed.
References
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Journal ArticleDOI
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex
TL;DR: The basal ganglia serve primarily to integrate diverse inputs from the entire cerebral cortex and to "funnel" these influences, via the ventrolateral thalamus, to the motor cortex.
Journal Article
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
Manish A. Shah,Nicole A. Datson,Lakshmi Srinidhi,Vincent P. Stanton,Marcy E. MacDonald,Marc W. Allard,S. Youngman,Anna-Maria Frischauf,Richard Mott,KM Draths,Günther Zehetner,C. O’Donovan,Thomas J. Fielder,Bruce G. Jenkins,Manju Swaroop,Sherryl A.M. Taylor,Lynn Doucette-Stamm,Heather MacFarlane,Scott A. Strobel,H. E. McFarlane,Alan Buckler,Nicolet Groot,Holger Hummerich,Deanna M. Church,M. A. Anderson,Marianne James,Glenn Barnes,M. Christine,Francis S. Collins,Mabel P. Duyao,Peter B. Dervan,Gillian P. Bates,T Holloway,Peter S. Harper,TW Mcdonald,M North,K Blanchard,John J. Wasmuth,D. Shaw,Hans Lehrach,Danilo A. Tagle,Annemarie Poustka,David E. Housman,T. Huntington,Zdenek Sedlacek,Laura Riba,Susan F. Kirby,Carol Lin,Richard H. Myers,Leslie M. Thompson,Russell G. Snell,Michael Conlon O'Donovan,K Gillespie,Rita Shiang,Nancy S. Wexler,Christine Ambrose,J. F. Gusella,Sarah Baxendale,N. Groat,John Valdes +59 more
TL;DR: The Huntington's disease mutation involves an unstable DNA segment, similar to those described in fragile X syndrome, spino-bulbar muscular atrophy, and myotonic dystrophy, acting in the context of a novel 4p16.3 gene to produce a dominant phenotype.
Journal ArticleDOI
The functional anatomy of basal ganglia disorders.
TL;DR: A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control.
Journal ArticleDOI
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
TL;DR: The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis as mentioned in this paper.
Book
The Cognitive Neurosciences
TL;DR: The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition -the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind as discussed by the authors.