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Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341) as discussed by the authors proposed a new method for the development of infants.Abstract:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (R01-HD028341)read more
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Opioidergic Modulation of Striatal Circuits, Implications in Parkinson's Disease and Levodopa Induced Dyskinesia.
Stefania Sgroi,Raffaella Tonini +1 more
TL;DR: This work reviews recent findings on the cell-type-specific effects of opioidergic neurotransmission in the dorsal striatum, focusing on the maladaptive synaptic neuroadaptations that occur in PD and levodopa-induced dyskinesia.
Journal ArticleDOI
The neostriatum: two entities, one structure?
Violeta G. Lopez-Huerta,Yoko Nakano,Johannes Bausenwein,Omar Jáidar,Michael Lazarus,Yoan Cherassse,Marianela Garcia-Munoz,Gordon W. Arbuthnott +7 more
TL;DR: It is reported that indeed these two areas do not exchange synaptic information between matrix and striosome, and inhibition of matrix neurons by systemic administration of DREADD agonist clozapine-n-oxide interfered with performance of the learned task.
Journal ArticleDOI
The Basal Ganglia Striosomes Affect the Modulation of Conflicts by Subliminal Information-Evidence from X-Linked Dystonia Parkinsonism.
Christian Beste,Moritz Mückschel,Raymond L. Rosales,Aloysius Domingo,Lillian V. Lee,Arlene Ng,Christine Klein,Alexander Münchau +7 more
TL;DR: The results suggest that conjoint effects between subliminal and conscious sources of conflicts are modulated by the striosomes and were stronger in XDP patients, suggesting that microstructural basal ganglia properties are relevant for cognitive control.
Journal ArticleDOI
Frizzled3 controls axonal polarity and intermediate target entry during striatal pathway development
Francesca Morello,Asheeta A. Prasad,Kati Rehberg,Renata Baptista Vieira de Sá,Noelia Antón-Bolaños,Eduardo Leyva-Díaz,Youri Adolfs,Fadel Tissir,Guillermina López-Bendito,R. Jeroen Pasterkamp +9 more
TL;DR: The embryonic ontogeny of the two main striatal pathways is determined and novel (non)cell-autonomous roles for the axon guidance receptor Frizzled3 in uncharacterized aspects of striatal pathway formation are identified, the first to identify a gene that provides anterior–posterior axon advice in a large brain nucleus.
Journal ArticleDOI
Action selection performance of a reconfigurable basal ganglia inspired model with Hebbian-Bayesian Go-NoGo connectivity.
TL;DR: The results show that there is not a unique best way to configure this BG model to handle well all the learning paradigms tested, and suggest that an agent might dynamically configure its action selection mode, possibly depending on task characteristics and also on how much time is available.
References
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Journal ArticleDOI
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex
TL;DR: The basal ganglia serve primarily to integrate diverse inputs from the entire cerebral cortex and to "funnel" these influences, via the ventrolateral thalamus, to the motor cortex.
Journal Article
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
Manish A. Shah,Nicole A. Datson,Lakshmi Srinidhi,Vincent P. Stanton,Marcy E. MacDonald,Marc W. Allard,S. Youngman,Anna-Maria Frischauf,Richard Mott,KM Draths,Günther Zehetner,C. O’Donovan,Thomas J. Fielder,Bruce G. Jenkins,Manju Swaroop,Sherryl A.M. Taylor,Lynn Doucette-Stamm,Heather MacFarlane,Scott A. Strobel,H. E. McFarlane,Alan Buckler,Nicolet Groot,Holger Hummerich,Deanna M. Church,M. A. Anderson,Marianne James,Glenn Barnes,M. Christine,Francis S. Collins,Mabel P. Duyao,Peter B. Dervan,Gillian P. Bates,T Holloway,Peter S. Harper,TW Mcdonald,M North,K Blanchard,John J. Wasmuth,D. Shaw,Hans Lehrach,Danilo A. Tagle,Annemarie Poustka,David E. Housman,T. Huntington,Zdenek Sedlacek,Laura Riba,Susan F. Kirby,Carol Lin,Richard H. Myers,Leslie M. Thompson,Russell G. Snell,Michael Conlon O'Donovan,K Gillespie,Rita Shiang,Nancy S. Wexler,Christine Ambrose,J. F. Gusella,Sarah Baxendale,N. Groat,John Valdes +59 more
TL;DR: The Huntington's disease mutation involves an unstable DNA segment, similar to those described in fragile X syndrome, spino-bulbar muscular atrophy, and myotonic dystrophy, acting in the context of a novel 4p16.3 gene to produce a dominant phenotype.
Journal ArticleDOI
The functional anatomy of basal ganglia disorders.
TL;DR: A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control.
Journal ArticleDOI
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
TL;DR: The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis as mentioned in this paper.
Book
The Cognitive Neurosciences
TL;DR: The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition -the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind as discussed by the authors.