BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway.
Yang Liu,Tai Yang,Hongyu Li,Minhui Li,Jin Liu,Yan-Tang Wang,Shu-Xia Yang,Zheng J,Xing-Yan Luo,Yi Lai,Ping Yang,Li-Mei Li,Qiang Zou +12 more
TLDR
A series of benzothiazole derivatives were screened for Immunosuppressive activity and BD750 was found to be the most effective immunosuppressant.Abstract:
Background and Purpose
A series of benzothiazole derivatives were screened for immunosuppressive activity; of these compounds BD750 was found to be the most effective immunosuppressant. The purpose of the current study was to determine the immunosuppressive activity of BD750 on T cell proliferation and its potential mode of action.read more
Citations
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Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2 + 2] Cycloaddition and C-H Functionalization
Min Zhou,Min Zhou,Xing-Ren Li,Jian-Wei Tang,Yang Liu,Xiao-Nian Li,Bin Wu,Hong-Bo Qin,Xue Du,Li-Mei Li,Wei-Guang Wang,Jian-Xin Pu,Han-Dong Sun +12 more
TL;DR: A concise stereocontrolled synthesis of scopariusicide A and its analogues with enhanced biological activities was efficiently achieved using the main diterpenoid isolated from this plant as a readily available starting material.
Journal ArticleDOI
Scopariusic acid, a new meroditerpenoid with a unique cyclobutane ring isolated from Isodon scoparius.
Min Zhou,Haibo Zhang,Wei-Guang Wang,Ning-Bo Gong,Rui Zhan,Xiao-Nian Li,Xue Du,Li-Mei Li,Yan Li,Yang Lu,Jian-Xin Pu,Han-Dong Sun +11 more
TL;DR: Scopariusic acid, a new ent-clerodane-based meroditerpenoid with a unique cyclobutane ring and an unusual 1-octen-3-ol substituent, together with its biosynthetic related compound 2, were isolated from the aerial parts of Isodon scoparius.
Journal ArticleDOI
Nitrogen-Containing Dihydro-β-agarofuran Derivatives from Tripterygium wilfordii
Yinggang Luo,Xiang Pu,Guoyong Luo,Min Zhou,Qi Ye,Yan Liu,Jian Gu,Hua-Yi Qi,Guo-You Li,Guolin Zhang +9 more
TL;DR: Tripterygiumine Q (26) exhibited immunosuppressive activity against human peripheral mononuclear cells with an IC50 value of 8.67 μM and showed no cytotoxicity, even at 100 μM, indicating that 26 may represent a novel scaffold for the development of new Immunosuppressants.
Journal ArticleDOI
Benwamycins A–G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces
Feng-Xian Yang,Jian-Ping Huang,Zhixiang Liu,Zhiyan Wang,Jing Yang,Jun Tang,Zhiyin Yu,Yijun Yan,Guoyin Kai,Sheng-Xiong Huang +9 more
TL;DR: Seven new trialkyl-substituted benzene derivatives named benwamycins A-G (1-7), together with three known congeners, 8-10, were isolated from culture broth of the soil-derived Streptomyces sp.
Journal ArticleDOI
K313, a novel benzoxazole derivative, exhibits anti-inflammatory properties via inhibiting GSK3β activity in LPS-induced RAW264.7 macrophages.
Bo-Bo Zhao,Hui-Jie Guo,Yang Liu,Luo Xingyan,Shu-Xia Yang,Yantang Wang,Xiao Leng,Chun-Fen Mo,Zou Qiang +8 more
TL;DR: Investigation of the anti‐inflammatory properties and the underlying molecular mechanism of K313 in lipopolysaccharide (LPS)‐induced RAW264.7 macrophages indicated that K313 exhibited anti‐ inflammation properties and revealed the potential mechanism.
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