Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
Beatrix Bartok,Gary S. Firestein +1 more
TLDR
Rheumatoid FLS develop a unique aggressive phenotype that increases invasiveness into the extracellular matrix and further exacerbates joint damage, and new agents that target FLS could potentially complement the current therapies without major deleterious effect on adaptive immune responses.Abstract:
Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant therapeutic advances. The pathogenesis of RA is complex and includes many cell types, including T cells, B cells, and macrophages. Fibroblast-like synoviocytes (FLS) in the synovial intimal lining also play a key role by producing cytokines that perpetuate inflammation and proteases that contribute to cartilage destruction. Rheumatoid FLS develop a unique aggressive phenotype that increases invasiveness into the extracellular matrix and further exacerbates joint damage. Recent advances in understanding the biology of FLS, including their regulation regulate innate immune responses and activation of intracellular signaling mechanisms that control their behavior, provide novel insights into disease mechanisms. New agents that target FLS could potentially complement the current therapies without major deleterious effect on adaptive immune responses.read more
Citations
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Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors
Nunzio Bottini,Gary S. Firestein +1 more
TL;DR: The dual behaviour of FLS in RA suggests that FLS- directed therapies could become a complementary approach to immune-directed therapies in this disease, and progress in targeting these cells is reviewed.
Journal ArticleDOI
Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis
Qiangzhe Zhang,Diana Dehaini,Yue Zhang,Julia Zhou,Xiangyu Chen,Lifen Zhang,Ronnie H. Fang,Weiwei Gao,Liangfang Zhang +8 more
TL;DR: A nanoparticle-based broad-spectrum anti-inflammatory strategy for rheumatoid arthritis management that can neutralize proinflammatory cytokines, suppress synovial inflammation, target deep into the cartilage matrix, and provide strong chondroprotection against joint damage is shown.
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Anti-inflammatory activity of natural dietary flavonoids
TL;DR: Current knowledge and underlying mechanisms on anti-inflammatory activities of flavonoids and their implicated effects in the development of various chronic inflammatory diseases are summarized.
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Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches.
Mi Hee Park,Jin Tae Hong +1 more
TL;DR: In this article, the authors proposed to inhibit NF-κB signaling in cancer and inflammatory diseases, such as rheumatoid arthritis, atherosclerosis, inflammatory bowel diseases, multiple sclerosis and malignant tumors.
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Taurine and inflammatory diseases
Janusz Marcinkiewicz,Ewa Kontny +1 more
TL;DR: This review summarizes the current knowledge concerning the role of taurine, TauCl and TauBr in the pathogenesis of inflammatory diseases initiated or propagated by MPO-derived oxidants.
References
More filters
Journal ArticleDOI
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Gary L. Johnson,Razvan Lapadat +1 more
TL;DR: Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes, and inhibitors of these enzymes are being explored as anticancer agents.
Journal ArticleDOI
Evolving concepts of rheumatoid arthritis
TL;DR: Based on the pathogenic mechanisms, specific therapeutic interventions can be designed to suppress synovial inflammation and joint destruction in rheumatoid arthritis.
Journal ArticleDOI
Overview of cell death signaling pathways
Zhaoyu Jin,Wafik S. El-Deiry +1 more
TL;DR: Changing attention is being focused on alternative signaling pathways leading to cell death including necrosis, autophagy, and mitotic catastrophe.
Journal ArticleDOI
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.
TL;DR: Investigating the effects of ligation of the fibronectin receptor (FnR) on gene expression in rabbit synovial fibroblasts demonstrated that signals leading to changes in gene expression are transduced by the FnR, a member of the integrin family of extracellular matrix receptors.
Journal ArticleDOI
Evidence that cytokines play a role in rheumatoid arthritis
TL;DR: This Review discusses the biologic contribution and therapeutic potential of the major cytokine families to RA pathology, focusing on molecules contained within the TNF-alpha, IL-1,IL-6, Il-23, and IL-2 families.
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