Journal ArticleDOI
Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases
J. R. Siewert,R. Kestlmeier,Raymonde Busch,K. Böttcher,J. D. Roder,J Müller,C. Fellbaum,Heinz Höfler +7 more
TLDR
The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.Abstract:
A retrospective immunohistological analysis of 100 patients with pT1-3 N0 and pT1-3 N1 gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN0 cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN0) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.read more
Citations
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Journal ArticleDOI
Lymphatic Involvement in Early Gastric Cancer Prevalence and Prognosis in France
Frédéric Borie,Bertrand Millat,Abe Fingerhut,Jean-Marie Hay,Pierre-Louis Fagniez,Brigitte De Saxce +5 more
TL;DR: It is suggested that both lymph node and lymphatic vessel involvement are important prognostic factors in patients with EGC and lymphadenectomy in EGC is important to identify the high-risk population for whom prognosis is worse.
Journal ArticleDOI
Lymph node dissection for gastric cancer.
H.J. Meyer,J. Jähne +1 more
TL;DR: Systematic lymph node dissection should be an integral part of the curative resection sought if lymphadenectomy is restricted to the removal of nodes only, and the lymph node ratio and number of lymph nodes involved are relevant prognostic parameters.
Journal ArticleDOI
Lymph Node Metastasis of Gastric Cancer
TL;DR: The status of LN metastasis including its molecular mechanisms is reviewed, and LN dissection for the treatment of gastric cancer is evaluated and sufficient results are not being obtained using various modalities.
Journal ArticleDOI
Proliferative activity of micrometastases in the lymph nodes of patients with gastric cancer.
TL;DR: Immunohistochemically detectable isolated tumour clusters with a diameter of less than 0·2 mm have been regarded as non‐metastatic lesions, because of a lack of proliferative activity.
Journal ArticleDOI
Detection of sentinel and non-sentinel lymph node micrometastases by complete serial sectioning and immunohistochemical analysis for gastric cancer
Kaname Ishii,Shinichi Kinami,Kenichiro Funaki,Hideto Fujita,Itasu Ninomiya,Sachio Fushida,Takashi Fujimura,Genichi Nishimura,Masato Kayahara +8 more
TL;DR: The concept that lymph node micrometastasis of gastric cancer spreads first to sentinel nodes casts doubt on the idea that sentinel lymph nodes spread first to non-sentinel nodes, and is supported by the results.
References
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Journal ArticleDOI
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