Journal ArticleDOI
Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases
J. R. Siewert,R. Kestlmeier,Raymonde Busch,K. Böttcher,J. D. Roder,J Müller,C. Fellbaum,Heinz Höfler +7 more
TLDR
The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.Abstract:
A retrospective immunohistological analysis of 100 patients with pT1-3 N0 and pT1-3 N1 gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN0 cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN0) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.read more
Citations
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Journal ArticleDOI
Vascular endothelial growth factor-C and -D expression correlates with lymph node micrometastasis in pN0 early gastric cancer.
Takaaki Arigami,Shoji Natsugoe,Yoshikazu Uenosono,Shigehiro Yanagita,Katsuhiko Ehi,Hideo Arima,Yuko Mataki,Akihiro Nakajo,Sumiya Ishigami,Takashi Aikou +9 more
TL;DR: The expression of VEGF‐C and ‐D in early gastric cancer is investigated and its relationship to lymph node micrometastasis determined by reverse transcription‐polymerase chain reaction (RT‐PCR) is analyzed.
Journal ArticleDOI
Concepts, Rationale, and Current Outcomes of Less Invasive Surgical Strategies for Early Gastric Cancer: Data from a quarter-century of experience in a single institution
TL;DR: The rationality of less invasive surgery employed for EGC is investigated, showing reduced morbidity and mortality, as well as no recurrence or cancer-related deaths.
Journal ArticleDOI
Improving the standard of lymph node retrieval after gastric cancer surgery
George B. Hanna,Iakovos Amygdalos,Melody Ni,Piers R. Boshier,Sameh Mikhail,J. Lloyd,Robert D. Goldin +6 more
TL;DR: To examine factors that influence lymph node count and to study the relationship between nodal size and metastatic involvement in gastric cancer.
Journal ArticleDOI
Therapeutic value of lymph node dissection and the clinical outcome for patients with gastric cancer.
Yoshihiko Maehara,Yoshihiro Kakeji,Tadashi Koga,Yasunori Emi,Hideo Baba,Kohei Akazawa,Keizo Sugimachi +6 more
TL;DR: Early tumor detection, standardized surgical treatment, including routine lymph node dissection, and improved perioperative management have led to increased survival time among patients with this malignancy in Japan.
Journal ArticleDOI
Should lymph node micrometastasis be considered in node staging for gastric cancer?: the significance of lymph node micrometastasis in gastric cancer.
Chang Min Lee,Jun Min Cho,You-Jin Jang,You-Jin Jang,Sungsoo Park,Sungsoo Park,Seong-Heum Park,Seong-Heum Park,Seungjoo Kim,Seungjoo Kim,Young Jae Mok,Young Jae Mok,Chong Suk Kim,Chong Suk Kim,Jong Han Kim,Jong Han Kim +15 more
TL;DR: Lymph node micrometastasis was clinically significant as a risk factor for recurrent gastric cancer and should be considered when estimating TNM stage for determining prognosis and the best treatment strategy.
References
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Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
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TNM classification of malignant tumours
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Regression models and life tables (with discussion
TL;DR: The drum mallets disclosed in this article are adjustable, by the percussion player, as to balance, overall weight, head characteristics and tone production of the mallet, whereby the adjustment can be readily obtained.
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).
Jacqueline Cordell,Brunangelo Falini,Wendy N. Erber,A. K. Ghosh,Zainalabideen Abdulaziz,S M MacDonald,Karen Pulford,Harald Stein,D Y Mason +8 more
TL;DR: The APAAP technique was found particularly suitable for labeling cell smears and for detecting low numbers of antigen-bearing cells in a specimen and could be used in conjunction with immunoperoxidase methods for double immunoenzymatic staining.