Journal ArticleDOI
Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases
J. R. Siewert,R. Kestlmeier,Raymonde Busch,K. Böttcher,J. D. Roder,J Müller,C. Fellbaum,Heinz Höfler +7 more
TLDR
The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.Abstract:
A retrospective immunohistological analysis of 100 patients with pT1-3 N0 and pT1-3 N1 gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN0 cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN0) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.read more
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Book ChapterDOI
Adenocarcinoma in Barrett’s Esophagus — Classification and Staging
TL;DR: Because of this increasing frequency a precise classification of adenocarcinomas of the gastro-esophageal junction becomes more important for daily surgical routine, necessary for planning the extent of resection as well as for the comparability of surgical results from different institutions.
Minimalresiduale Tumorerkrankung bei gastrointestinalen Karzinomen : Prognoserelevanz und onkologisch-chirurgische Konsequenzen [Minimal residual tumor in gastrointestinal carcinoma: Relevance to prognosis and oncologic surgical consequences]
TL;DR: Isolated tumor cells as a consequence of minimal residual disease are often not detectable by routine diagnostic procedures as discussed by the authors, however, before or after surgery, isolated tumor cells in lymph nodes, peritoneal cavity, blood, or bone marrow can frequently be identified by immunohistochemical or molecular methods.
Journal ArticleDOI
Bedeutung disseminierter tumorzellen bei gastrointestinalen tumoren
TL;DR: The objective of new studies should be to guide adjUvant therapy through detection of isolated disseminated tumor cells and to monitor the efficacy of adjuvant therapy by follow-up examinations.
Journal ArticleDOI
Effects of systematic lymphadenectomy on length of survival in patients with gastric carcinoma
TL;DR: D2 lympahedenectomy is a standard procedure for a great number of patients with gastric carcinoma, with high survival rate, and only in the group of advanced gastric cancer, patients undergoing more radical types of lymphadenectomies (D2+, D3) presented with better survival rates.
Journal ArticleDOI
Nodal micrometastases status--will it influence decisions on surgical and adjuvant treatment for breast cancer?
H. Harissis,M. Fatouros +1 more
TL;DR: An analysis of the Surveillance, Epidemiology, and End Results (SEER) database for 209,720 breast cancer patients treated in the USA between 1992 and 2003 suggests N1 micrometastatic disease (N1mi) was a significant prognostic indicator.
References
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Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).
Jacqueline Cordell,Brunangelo Falini,Wendy N. Erber,A. K. Ghosh,Zainalabideen Abdulaziz,S M MacDonald,Karen Pulford,Harald Stein,D Y Mason +8 more
TL;DR: The APAAP technique was found particularly suitable for labeling cell smears and for detecting low numbers of antigen-bearing cells in a specimen and could be used in conjunction with immunoperoxidase methods for double immunoenzymatic staining.