Journal ArticleDOI
Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases
J. R. Siewert,R. Kestlmeier,Raymonde Busch,K. Böttcher,J. D. Roder,J Müller,C. Fellbaum,Heinz Höfler +7 more
TLDR
The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.Abstract:
A retrospective immunohistological analysis of 100 patients with pT1-3 N0 and pT1-3 N1 gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN0 cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN0) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.read more
Citations
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Prediction of risk factors for lymph node metastasis in early gastric cancer
TL;DR: The depth of invasion was the only independent risk factor for lymph node metastases in EGC and risk factors for metastases should be considered when choosing surgery for EGC.
Journal ArticleDOI
Assessment of lymph node micrometastasis in early gastric cancer in relation to sentinel nodes.
TL;DR: The indications for current EMR and reduced surgery in early gastric cancer are valid from the standpoint of micrometastases but if the SNNS that has been studied in recent years is introduced, the lymphatic basin dissection method seems valid only if the case is s-pN0 early cancer.
Journal ArticleDOI
Clinical relevance of occult tumor cells in lymph nodes from gastric cancer patients.
Fania S. Doekhie,Wilma E. Mesker,J. Han van Krieken,Niels F M Kok,Henk H. Hartgrink,Elma Meershoek – Klein Kranenbarg,Hein Putter,Peter J. K. Kuppen,Hans J. Tanke,Rob A. E. M. Tollenaar,Cornelis J.H. van de Velde +10 more
TL;DR: In this article, the relation between disease recurrence and the presence of occult tumor cells (OTC) in lymph nodes from gastric cancer patients was evaluated, and the results showed that OTC-positive lymph nodes were the only significant independent risk factor for disease recurrences.
Journal ArticleDOI
Detection and clinical implications of minimal residual disease in gastro-intestinal cancer
TL;DR: This review critically evaluates the prognostic impact of MRD in patients with pancreatic, colorectal and gastric cancer by outlining those studies showing diagnostic results of DTC detection in lymph nodes, bone marrow, venous blood and peritoneal lavage, some of which present novel strategies.
The Value of PET Imaging in Patients with Localized Gastroesophageal Cancer.
TL;DR: The MUNICON I study recently showed the utility of fluorodeoxyglucose-positron emission tomography (FDG-PET) in predicting response and prognosis in AEG and indicated the feasibility of a PET-guided treatment algorithm, an important step forward in tailoring multimodal treatment to tumor biology.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
BookDOI
TNM classification of malignant tumours
TL;DR: Head and Neck Tumours.- Lip and Oral Cavity.- Pharynx.- Larynx.' Maxillary Sinus.- Salivary Glands.- Thyroid Gland.- Digestive System Tumour .
Regression models and life tables (with discussion
TL;DR: The drum mallets disclosed in this article are adjustable, by the percussion player, as to balance, overall weight, head characteristics and tone production of the mallet, whereby the adjustment can be readily obtained.
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).
Jacqueline Cordell,Brunangelo Falini,Wendy N. Erber,A. K. Ghosh,Zainalabideen Abdulaziz,S M MacDonald,Karen Pulford,Harald Stein,D Y Mason +8 more
TL;DR: The APAAP technique was found particularly suitable for labeling cell smears and for detecting low numbers of antigen-bearing cells in a specimen and could be used in conjunction with immunoperoxidase methods for double immunoenzymatic staining.