Journal ArticleDOI
Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases
J. R. Siewert,R. Kestlmeier,Raymonde Busch,K. Böttcher,J. D. Roder,J Müller,C. Fellbaum,Heinz Höfler +7 more
TLDR
The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.Abstract:
A retrospective immunohistological analysis of 100 patients with pT1-3 N0 and pT1-3 N1 gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN0 cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN0) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastric cancer surgery in patients with lymph node metastasis.read more
Citations
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Journal ArticleDOI
Early gastric cancer: concepts, diagnosis, and management.
Hitoshi Katai,Takeshi Sano +1 more
TL;DR: The clinicopathological features of the disease and their prognostic significance have been meticulously investigated in Japan in studies based on large numbers of cases, sometimes exceeding 1000, and in the West, EGC remains a rare condition, and the number of EGC patients in Western series is usually small, although some European studies
Journal ArticleDOI
Surgery for gastric cancer: 10-year experience worldwide.
TL;DR: Although randomized controlled trials in Europe showed no survival benefit of D2 resection over D1 resection, the results must be interpreted with caution and cannot be extrapolated to Japanese patients, because the morbidity and mortality after D2 gastrectomy in Japan are much less than those after D1 gast rectomy in Europe.
Journal ArticleDOI
Sentinel node mapping during laparoscopic distal gastrectomy for gastric cancer
Elena Orsenigo,Carlo Staudacher +1 more
TL;DR: The goal of this study was to evaluate the feasibility and accuracy of sentinel node (SN) mapping with endoscopic submucosal blue dye injection during laparoscopic distal gastrectomy for gastric cancer.
Journal ArticleDOI
Changes in treatment outcomes of gastric cancer surgery over 45 years at a single institution.
Woo Jin Hyung,Sungsoo Kim,Won Hyuk Choi,Jae Ho Cheong,Seung Ho Choi,Choong Bai Kim,Sung Hoon Noh +6 more
TL;DR: In this paper, a study was conducted to evaluate changes in host, tumor, and treatment factors in patients treated at a single institution over a period of 45 years, and remarkable changes were noted in host and tumor factors, and prognosis.
Book ChapterDOI
Potential and futility of sentinel node detection for gastric cancer.
J. R. Siewert,A. Sendler +1 more
TL;DR: The rationale, aims, and extent of LA in gastric cancer are addressed, and the scientific discussion on whether D1 or an extended lymphadenectomy are appropriate is not finally closed as yet.
References
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Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).
Jacqueline Cordell,Brunangelo Falini,Wendy N. Erber,A. K. Ghosh,Zainalabideen Abdulaziz,S M MacDonald,Karen Pulford,Harald Stein,D Y Mason +8 more
TL;DR: The APAAP technique was found particularly suitable for labeling cell smears and for detecting low numbers of antigen-bearing cells in a specimen and could be used in conjunction with immunoperoxidase methods for double immunoenzymatic staining.