Bioactive compounds from marine bacteria and fungi.
TLDR
This review covers new biologically active natural products published recently and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.Abstract:
Summary
Marine bacteria and fungi are of considerable importance as new promising sources of a huge number of biologically active products. Some of these marine species live in a stressful habitat, under cold, lightless and high pressure conditions. Surprisingly, a large number of species with high diversity survive under such conditions and produce fascinating and structurally complex natural products. Up till now, only a small number of microorganisms have been investigated for bioactive metabolites, yet a huge number of active substances with some of them featuring unique structural skeletons have been isolated. This review covers new biologically active natural products published recently (2007–09) and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.read more
Citations
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Journal ArticleDOI
Bacterial-fungal interactions: ecology, mechanisms and challenges.
Aurélie Deveau,Gregory Bonito,Jessie K. Uehling,Jessie K. Uehling,Mathieu Paoletti,Matthias Becker,Saskia Bindschedler,Stéphane Hacquard,Vincent Hervé,Jessy Labbé,Jessy Labbé,Olga A. Lastovetsky,Sophie Mieszkin,Larry J. Millet,Balázs Vajna,Pilar Junier,Paola Bonfante,Bastiaan P. Krom,Stefan Olsson,Jan Dirk van Elsas,Lukas Y. Wick +20 more
TL;DR: A particular focus is placed on the understanding of BFI within complex microbial communities and in regard of the metaorganism concept, as well as recent discoveries that clarify the (molecular) mechanisms involved in bacterial-fungal relationships.
Journal ArticleDOI
The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview
TL;DR: This paper will provide an update on the antiviral actions of the sulfated polysaccharides derived from marine algae including carrageenans, alginates, and fucans, relating to their structure features and the structure–activity relationships.
Journal ArticleDOI
Marine compounds and their antiviral activities.
Jarred Yasuhara-Bell,Yuanan Lu +1 more
TL;DR: The growing interest in marine-derived antiviral compounds, along with the development of new technology in marine cultures and extraction, will significantly expedite the current exploration of the marine environment for compounds with significant pharmacological applications.
Journal ArticleDOI
Bioactive Pigments from Marine Bacteria: Applications and Physiological Roles
TL;DR: The biological activities of marine compounds are reviewed, including recent advances in the study of pharmacological effects and other commercial applications, in addition to the biosynthesis and physiological roles of associated pigments.
Journal ArticleDOI
Bioactive secondary metabolites from endophytes and associated marine derived fungi
TL;DR: This review covers the literature published in 2010 and highlights new bioactive metabolites and known compounds for which hitherto novel biological activities have been reported.
References
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Journal ArticleDOI
Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal Article
On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to their Use in the Isolation of B. influenzæ
TL;DR: It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes, and its value as an aid to the isolation of B. influenzae has been demonstrated.
Journal ArticleDOI
Fungal secondary metabolism — from biochemistry to genomics
TL;DR: Questions are addressed, including which evolutionary pressures led to gene clustering, why closely related species produce different profiles of secondary metabolites, and whether fungal genomics will accelerate the discovery of new pharmacologically active natural products.
Journal ArticleDOI
Drug development from marine natural products
Tadeusz F. Molinski,Doralyn S. Dalisay,Sarah L. Lievens,Sarah L. Lievens,Jonel P. Saludes,Jonel P. Saludes +5 more
TL;DR: The history of drug discovery from marine natural products is reviewed, and by describing selected examples, the factors that contribute to new discoveries and the difficulties associated with translating marine-derived compounds into clinical trials are examined.
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