Journal ArticleDOI
Bioactive marine metabolites. Part 16. Calyculin A. A novel antitumor metabolite from the marine sponge Discodermia calyx
Yuko Kato,Nobuhiro Fusetani,Shigeki Matsunaga,Kanehisa Hashimoto,Shigeo Fujita,Toshio Furuya +5 more
Reads0
Chats0
About:
This article is published in Journal of the American Chemical Society.The article was published on 1986-05-01. It has received 285 citations till now. The article focuses on the topics: Calyculin & Calyx.read more
Citations
More filters
Journal ArticleDOI
A molecular basis for different interactions of marine toxins with protein phosphatase-1. Molecular models for bound motuporin, microcystins, okadaic acid, and calyculin A.
TL;DR: It is shown here that the free NMR solution structures of two distinct microcystin structural congeners are remarkably similar to the bound crystal structure of micro Cystin-LR, and Metropolis Monte Carlo modeling is used to dock the known free crystal structures of okadaic acid and calyculin A to the Crystal structure of PP-1c.
Journal ArticleDOI
Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins.
TL;DR: The okadaic acid class of naturally occurring toxins is a structurally diverse group of molecules that inhibit the protein phosphatases PP1 and PP2A.
Journal ArticleDOI
Callipeltin A, an Anti-HIV Cyclic Depsipeptide from the New Caledonian Lithistida Sponge Callipelta sp.
Angela Zampella,Maria Valeria D'Auria,L. Gomez Paloma,Agostino Casapullo,Luigi Minale,Cécile Debitus,Y. Hénin +6 more
TL;DR: Callipeltin A, a cyclic depsidecapeptide from a shallow water sponge of the genus Callipelta, has been found to protect cells infected by human immunodeficiency (HIV) virus.
Journal ArticleDOI
Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells
Masao Ito,Laddawan Karachot +1 more
TL;DR: The results suggest that AMPA receptors are persistently desensitized due to concerted action of both an agonist and an enzymatic system involving protein kinases G and C and a protein phosphatase inhibitor.
Journal ArticleDOI
From Propargylic Amides to Functionalized Oxazoles: Domino Gold Catalysis/Oxidation by Dioxygen
TL;DR: A new, highly efficient, and atom-economic access to a series of functionalized 2,5-disubstituted oxazoles from propargylic amides is reported and experiments addressing the reaction mechanism reveal a radical pathway for this autoxidation process.