Journal ArticleDOI
Biodegradable and elastomeric vascular grafts enable vascular remodeling
Meifeng Zhu,Yifan Wu,Wen Li,Dong Xianhao,Hong Chang,Kai Wang,Pingli Wu,Jun Zhang,Guanwei Fan,Lianyong Wang,Jianfeng Liu,Hongjun Wang,Deling Kong +12 more
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TLDR
This strategy represents a new avenue for guided tissue regeneration by designing the grafts to promote tissue remodeling via controlling structure, degradation and mechanical properties of the scaffolds.About:
This article is published in Biomaterials.The article was published on 2018-09-01. It has received 74 citations till now.read more
Citations
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Chemical Surface Modification of Polymeric Biomaterials for Biomedical Applications.
TL;DR: This review focuses on the attachment of polymer brushes to polymeric biomaterial substrates by chemical surface modification methods for biomedical applications and a perspective on future trends in this field is provided.
Journal ArticleDOI
Artificial small-diameter blood vessels: materials, fabrication, surface modification, mechanical properties, and bioactive functionalities
TL;DR: In this review, the progress and potential outlook of small-diameter blood vessels (SDBVs) engineered in vitro are highlighted and summarized, including material selection and development, fabrication techniques, surface modification, mechanical properties, and bioactive functionalities.
Journal ArticleDOI
Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration.
Dong Xianhao,Siyang Liu,Yueyue Yang,Shan Gao,Wenlei Li,Jiasong Cao,Ye Wan,Ziqi Huang,Guanwei Fan,Quan Chen,Hongjun Wang,Meifeng Zhu,Meifeng Zhu,Deling Kong +13 more
TL;DR: In this paper, the topological cues delivered by biomaterials in promotion of oriented tissue regeneration (e.g., peripheral nerve regrowth) remains largely elusive, and the regulatory mechanism of microfiber orientation on promoted peripheral nerve regeneration is investigated.
Journal ArticleDOI
Local Delivery of Dual MicroRNAs in Trilayered Electrospun Grafts for Vascular Regeneration.
Meiling Wen,Dengke Zhi,Lina Wang,Ce Cui,Ziqi Huang,Yunhui Zhao,Kai Wang,Deling Kong,Xiaoyan Yuan +8 more
TL;DR: Findings indicated that the trilayered electrospun graft by local delivery of dual miRNAs could be possibly used as a bioactive substitute for replacement of artificial small-caliber blood vessels.
Journal ArticleDOI
Construction of vascular graft with circumferentially oriented microchannels for improving artery regeneration.
Pingli Wu,Lina Wang,Wen Li,Yu Zhang,Yifan Wu,Dengke Zhi,Hongjun Wang,Lianyong Wang,Deling Kong,Meifeng Zhu,Meifeng Zhu +10 more
TL;DR: This research provides a new strategy for the fabrication of grafts with the capability of inducing arterial regeneration, which could be further extended to apply in preparing other kinds of oriented scaffolds aiming to guide oriented tissue in situ regeneration.
References
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Journal ArticleDOI
Functional arteries grown in vitro.
Laura E. Niklason,Jinming Gao,William M. Abbott,Karen K. Hirschi,S. Houser,Robert P. Marini,Robert Langer +6 more
TL;DR: A tissue engineering approach was developed to produce arbitrary lengths of vascular graft material from smooth muscle and endothelial cells that were derived from a biopsy of vascular tissue, with patency documented up to 24 days by digital angiography.
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The Emerging Concept of Vascular Remodeling
Gary H. Gibbons,Victor J. Dzau +1 more
TL;DR: Vascular remodeling is an active process of structural alteration that involves changes in at least four cellular processes -- cell growth, cell death, cell migration, and production or degradation of extracellular matrix -- and is dependent on a dynamic interaction between locally.
Journal ArticleDOI
A completely biological tissue-engineered human blood vessel
TL;DR: This is the first completely biological TEBV to display a burst strength comparable to that of human vessels, and this novel technique can produce completely biological vessels fulfilling the fundamental requirements for grafting: high burst strength, positive surgical handling, and a functional endothelium.
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A blood vessel model constructed from collagen and cultured vascular cells
Crispin B. Weinberg,Eugene Bell +1 more
TL;DR: A model of a blood vessel was constructed in vitro and electron microscopy showed that the endothelial cells lining the lumen and the smooth muscle cells in the wall were healthy and well differentiated.
Journal ArticleDOI
Human tissue-engineered blood vessels for adult arterial revascularization
Nicolas L'Heureux,Nathalie Dusserre,Gerhardt Konig,Braden Victor,Paul A. Keire,Thomas N. Wight,Nicolas Chronos,Andrew E. Kyles,Clare R. Gregory,Grant Hoyt,Robert C. Robbins,Todd N. McAllister +11 more
TL;DR: These results indicate that a completely biological and clinically relevant TEBV can be assembled exclusively from an individual's own cells, without relying upon synthetic or exogenous scaffolding.