Biodemography of human ageing.
TLDR
Research by demographers, epidemiologists and other biomedical researchers suggests that further progress is likely to be made in advancing the frontier of survival — and healthy survival — to even greater ages.Abstract:
Human senescence has been delayed by a decade. This finding, documented in 1994 and bolstered since, is a fundamental discovery about the biology of human ageing, and one with profound implications for individuals, society and the economy. Remarkably, the rate of deterioration with age seems to be constant across individuals and over time: it seems that death is being delayed because people are reaching old age in better health. Research by demographers, epidemiologists and other biomedical researchers suggests that further progress is likely to be made in advancing the frontier of survival — and healthy survival — to even greater ages.read more
Citations
More filters
Journal ArticleDOI
HIV Infection, Inflammation, Immunosenescence, and Aging
TL;DR: Novel therapeutic strategies aimed at preventing or reversing these immunologic defects that persist despite effective suppression of HIV replication may be necessary if HIV-infected patients are to achieve normal life span.
Nothing in Biology Makes Sense Except in the Light of Evolution
TL;DR: The theory that biological species are descended from common ancestors provides an indispensable heuristic to understand why living organisms are what they are and do what they do.
Journal ArticleDOI
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Marjolein P. Baar,Renata M. C. Brandt,Diana A. Putavet,Julian D.D. Klein,Kasper W.J. Derks,Benjamin Bourgeois,Sarah Stryeck,Yvonne Rijksen,Hester van Willigenburg,Danny A. Feijtel,Ingrid van der Pluijm,Jeroen Essers,Wiggert A. van Cappellen,Wilfred F. J. van IJcken,Adriaan B Houtsmuller,Joris Pothof,Ron W. F. de Bruin,Tobias Madl,Jan H.J. Hoeijmakers,Judith Campisi,Judith Campisi,Peter L.J. de Keizer,Peter L.J. de Keizer +22 more
TL;DR: Treatment targeting of senescent cells is feasible under conditions where loss of health has already occurred, and in doing so tissue homeostasis can effectively be restored.
Journal ArticleDOI
Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble
Vasilis Kontis,James E. Bennett,Colin Mathers,Guangquan Li,Guangquan Li,Kyle J Foreman,Kyle J Foreman,Majid Ezzati +7 more
TL;DR: There is more than a 50% probability that by 2030, national female life expectancy will break the 90 year barrier, a level that was deemed unattainable by some at the turn of the 21st century.
Journal ArticleDOI
Diversity of ageing across the tree of life
Owen R. Jones,Alexander Scheuerlein,Roberto Salguero-Gómez,Carlo Giovanni Camarda,Ralf Schaible,Brenda B. Casper,Johan P. Dahlgren,Johan Ehrlén,María B. García,Eric S. Menges,Pedro F. Quintana-Ascencio,Hal Caswell,Annette Baudisch,James W. Vaupel +13 more
TL;DR: Great variation among these species, including increasing, constant, decreasing, humped and bowed trajectories for both long- and short-lived species, challenges theoreticians to develop broader perspectives on the evolution of ageing and empiricists to study the demography of more species.
References
More filters
Journal ArticleDOI
Oxidative Stress, Caloric Restriction, and Aging
TL;DR: Support for this hypothesis includes the following observations: (i) Overexpression of antioxidative enzymes retards the age-related accrual of oxidative damage and extends the maximum life-span of transgenic Drosophila melanogaster and (ii) Variations in longevity among different species inversely correlate with the rates of mitochondrial generation of the superoxide anion radical and hydrogen peroxide.
Journal ArticleDOI
Ageing populations: the challenges ahead
TL;DR: Research suggests that ageing processes are modifiable and that people are living longer without severe disability, and this finding will be important for the chances to meet the challenges of ageing populations.
Journal ArticleDOI
Aging, natural death, and the compression of morbidity.
TL;DR: The average age at first infirmity can be raised, thereby making the morbidity curve more rectangular, and present data allow calculation of the ideal average life span, approximately 85 years.
Journal ArticleDOI
Broken Limits to Life Expectancy
Jim Oeppen,James W. Vaupel +1 more
TL;DR: The evidence presented in this paper suggests that the apparent leveling off of life expectancy in various countries is an artifact of laggards catching up and leaders falling behind, not a sign that life expectancy is approaching its limit.
Journal ArticleDOI
The impact of heterogeneity in individual frailty on the dynamics of mortality.
TL;DR: Calculations based on Swedish mortality data suggest that standard methods overestimate current life expectancy and potential gains in life expectancy from health and safety interventions, while underestimating rates of individual aging, past progress in reducing mortality, and mortality differentials between pairs of populations.