Biomarker correlates of survival in pediatric patients with Ebola virus disease.
Anita K. McElroy,Bobbie R. Erickson,Timothy D. Flietstra,Pierre E. Rollin,Stuart T. Nichol,Jonathan S. Towner,Christina F. Spiropoulou +6 more
TLDR
Children who had certain endothelial and immune function markers were more likely to survive infection and be diagnosed with infection later in life.Abstract:
Outbreaks of Ebola virus disease (EVD) occur sporadically in Africa and are associated with high case-fatality rates. Historically, children have been less affected than adults. The 2000–2001 Sudan virus–associated EVD outbreak in the Gulu district of Uganda resulted in 55 pediatric and 161 adult laboratory-confirmed cases. We used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from that outbreak to identify biomarkers specific to pediatric disease. Pediatric patients who survived had higher levels of the chemokine regulated on activation, normal T-cell expressed and secreted marker and lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did pediatric patients who died. Adult patients had similar levels of these analytes regardless of outcome. Our findings suggest that children with EVD may benefit from different treatment regimens than those for adults.read more
Citations
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A retrospective cohort study: 10-year trend of disease-modifying antirheumatic drugs and biological agents use in patients with rheumatoid arthritis at Veteran Affairs Medical Centers.
TL;DR: Methotrexate use increased as it became the preferred first-line agent, while other traditional agents declined, and a significant shorter time between RA diagnosis and DMARD or biological agent initiation in recent years suggests improvements in quality of care.
Journal ArticleDOI
Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus
Xuan Liu,Emily Speranza,César Muñoz-Fontela,César Muñoz-Fontela,Sam Haldenby,Natasha Y. Rickett,Isabel García-Dorival,Yongxiang Fang,Yper Hall,Elsa Gayle Zekeng,Anja Lüdtke,Anja Lüdtke,Dong Xia,Romy Kerber,Ralf Krumkamp,Sophie Duraffour,Daouda Sissoko,John Kenny,Nichola Rockliffe,E. Diane Williamson,Thomas R. Laws,Magassouba N’Faly,David A. Matthews,Stephan Günther,Andrew R. Cossins,Armand Sprecher,John H. Connor,Miles W. Carroll,Miles W. Carroll,Julian A. Hiscox +29 more
TL;DR: This paper used transcriptome data for peripheral blood taken from infected and convalescent recovering patients to identify early stage host factors that are associated with acute illness and those that differentiate patient survival from fatality.
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Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus.
Judith R. Glynn,Hilary Bower,Sembia Johnson,Catherine F Houlihan,Carla Montesano,Carla Montesano,Carla Montesano,Janet T Scott,Malcolm G Semple,Mohammed S Bangura,Alie Kamara,Osman Kamara,Saidu H. Mansaray,Daniel Sesay,Cecilia Turay,Steven Dicks,Raoul Emeric Guetiya Wadoum,Raoul Emeric Guetiya Wadoum,Raoul Emeric Guetiya Wadoum,Vittorio Colizzi,Vittorio Colizzi,Vittorio Colizzi,Francesco Checchi,Dhan Samuel,Richard S. Tedder +24 more
TL;DR: The low prevalence of this new highly specific and sensitive assay showed asymptomatic infection with Ebola virus was uncommon despite high exposure, and even if infectious, would account for few transmissions.
Journal ArticleDOI
Clinical presentation and management of severe Ebola virus disease.
TL;DR: Clinicians caring for patients infected with Ebola virus must be familiar not only with screening and infection control measures but also with management of severe disease by integrating experience from several Ebola epidemics with best practices for managing critical illness.
Journal ArticleDOI
Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis
TL;DR: In this paper, the authors search for articles about any African filovirus, and summarize narratively with partial meta-analysis, concluding that transmission is unlikely except through close contact, especially during the most severe stages of acute illness.
References
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