Reference EntryDOI
Biomaterials: Tissue Engineering and Scaffolds
TLDR
To approach a more natural three-dimensional environment necessary for successful organ and tissue transplantation, the combined efforts of researchers from the fields of biology, biochemistry, and material science/engineering will be needed to further develop scaffolds that will support biological signals for tissue growth and reorganization.Abstract:
Tissue engineering offers an alternative to whole organ and tissue transplantation for diseased, failed, or abnormally functioning organs. Tissue engineering requires a triad of components: (1) Harvested and dissociated cells from the donor tissue; (2) scaffolds made of biomaterials on which cells are attached and cultured, then implanted at the desired site in functioning tissue; and (3) growth factors that promote and/or prevent cell adhesion, proliferation, migration, and differentiation by up-regulating or down-regulating the synthesis of protein, growth factors, and receptors.
Of these three key components, scaffolds be play a critical role. Scaffolds direct the growth (1) of cells seeded within the porous structure of the scaffold, or (2) of cells migrating from the surrounding tissue, to eventually mimick a natural extracellular matrix. In this section, a review is given of the biomaterials and procedures used in the development of tissue-engineered scaffolds, including: (1) natural and synthetic, polymeric biomaterials (2) bioceramic scaffolds, (3) cytokine-released scaffolds, (4) the fabrication and characterization of scaffolds, (5) surface modifications, and (6) scaffold sterilization. However, to approach a more natural three-dimensional environment necessary for successful organ and tissue transplantation, the combined efforts of researchers from the fields of biology, biochemistry, and material science/engineering will be needed to further develop scaffolds that will support biological signals for tissue growth and reorganization.
Keywords:
tissue engineering;
scaffolds;
biocompatibility;
biomaterials;
polymersread more
Citations
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Sun-Jung Yoon,Soon Hee Kim,Hyun Jung Ha,Youn Kyung Ko,Jung Won So,Moon Suk Kim,Young Il Yang,Gilson Khang,John M. Rhee,Hai Bang Lee +9 more
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Meifeng Zhu,Kai Wang,Jingjing Mei,Chen Li,Jiamin Zhang,Wenting Zheng,Di An,Nannan Xiao,Qiang Zhao,Deling Kong,Deling Kong,Lianyong Wang +11 more
TL;DR: It is proposed that the SF porous scaffold fabricated here may be an attractive candidate for use as a potential vascular graft for implantation based on its high porosity, excellent blood compatibility and mild fabrication process.
References
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