Journal ArticleDOI
Biomimetic Materials for Bone Tissue Engineering – State of the Art and Future Trends
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TLDR
Several biomimetic approaches involving hydrogels or particles for 3‐dimensional (3D) cell cultures are reviewed and it is suggested that the 3D culture of several cell populations should make it easier for bone tissue constructs to vascularize, thus lifting the limits of current clinical applications.Abstract:
Bone tissue engineering is extremely promising for regenerating large bone defects in orthopedic or maxillofacial surgery. It consists of harvesting, culturing and differentiating human mesenchymal stem cells in combination with scaffolds. Different cell sources, such as bone marrow or adipose tissue, have been studied. Biomaterials resembling bone extracellular matrix have been used for scaffolding cells. However, these macroporous calcium phosphate ceramics or biodegradable polymers are two dimensional structures at the cellular level and have low osteogenesis properties in vivo. In this paper, several biomimetic approaches involving hydrogels or particles for 3-dimensional (3D) cell cultures are reviewed. High numbers of cells for low amounts of material induced abundant extracellular matrix formation in vitro and relatively large amounts of bone tissue formation in vivo. In addition, the 3D culture of several cell populations should make it easier for bone tissue constructs to vascularize, thus lifting the limits of current clinical applications.read more
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Journal ArticleDOI
An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering
TL;DR: The analysis of the state of the art in the field reveals the presence of current innovative techniques for scaffolds and material manufacturing that are currently opening the way to prepare biomimetic PLGA substrates able to modulate cell interaction for improved substitution, restoration, or enhancement of bone tissue function.
Journal ArticleDOI
Injectable hydrogels for cartilage and bone tissue engineering.
Mei Liu,Xin Zeng,Chao Ma,Huan Yi,Zeeshan Ali,Zeeshan Ali,Xianbo Mou,Song Li,Yan Deng,Yan Deng,Nongyue He,Nongyue He +11 more
TL;DR: The selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering are described and the biology of Cartilage and the bony ECM is summarized.
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Peptide-based stimuli-responsive biomaterials
TL;DR: In this paper, the authors explore recent advances in the design and engineering of materials wholly or principally constructed from peptides, and focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular structure.
Journal ArticleDOI
Silk protein-based hydrogels: Promising advanced materials for biomedical applications
Sonia Kapoor,Subhas C. Kundu +1 more
TL;DR: This review provides overview of the advances in silk protein-based hydrogels with a primary emphasis on hydrogel of fibroin with the aim of highlighting the research that has been done in the area of silk-basedHydrogels.
Journal ArticleDOI
Vascularized bone tissue engineering: approaches for potential improvement.
Lonnissa H. Nguyen,Nasim Annabi,Nasim Annabi,Mehdi Nikkhah,Hojae Bae,Hojae Bae,Loïc Binan,Sang-Won Park,Yunqing Kang,Yunzhi Yang,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini +12 more
TL;DR: The limitations of current bone TE approaches are reviewed and possible strategies to improve vascularization in bone tissue substitutes are discussed.
References
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Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
Journal ArticleDOI
Multilineage cells from human adipose tissue: implications for cell-based therapies.
Patricia A. Zuk,Min Zhu,Hiroshi Mizuno,Jerry I. Huang,Futrell Jw,Adam J. Katz,Prosper Benhaim,H. P. Lorenz,Marc H. Hedrick +8 more
TL;DR: The data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs.
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Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
Journal ArticleDOI
Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.