Journal ArticleDOI
Bioorthogonal dual functionalization of self-assembling peptide fibers
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TLDR
Self-Assembling peptide Fibers (SAFs) can incorporate multiple modified peptides non-covalently, stoichiometrically and without disrupting their structure or stability.About:
This article is published in Biomaterials.The article was published on 2011-05-01. It has received 58 citations till now. The article focuses on the topics: Self-assembling peptide & Click chemistry.read more
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Peptide-based stimuli-responsive biomaterials
TL;DR: In this paper, the authors explore recent advances in the design and engineering of materials wholly or principally constructed from peptides, and focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular structure.
Journal ArticleDOI
Modulating adaptive immune responses to peptide self-assemblies.
Jai S. Rudra,Tao Sun,Katelyn C. Bird,Melvin D. Daniels,Joshua Z. Gasiorowski,Anita S. Chong,Joel H. Collier +6 more
TL;DR: This work investigates the molecular determinants and immunological mechanisms leading to the significant immunogenicity of the self-assembling peptide OVA-Q11, which has been shown previously to elicit strong antibody responses in mice, and shows that these responses can last for at least a year.
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From short peptides to nanofibers to macromolecular assemblies in biomedicine.
TL;DR: A comprehensive review of short peptides that form nanofibrous hydrogels that consist exclusively of simple amino acids and recent advances in peptide assembly motifs and applications is focused on.
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Designer nanomaterials using chiral self-assembling peptide systems and their emerging benefit for society
Zhongli Luo,Shuguang Zhang +1 more
TL;DR: The field of chiral self-assembling peptide nanobiotechnology is growing in a number of directions that has led to many surprises in areas of novel materials, synthetic biology, clinical medicine and beyond.
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Fluorescence in nanobiotechnology: sophisticated fluorophores for novel applications.
TL;DR: This review covers the growing utility of different classes of fluorophores in nanobiotechnology, from both a photophysical and a chemical perspective.
References
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Journal ArticleDOI
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
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Click Chemistry: Diverse Chemical Function from a Few Good Reactions.
TL;DR: In this paper, a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach called click chemistry is defined, enabled, and constrained by a handful of nearly perfect "springloaded" reactions.
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Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.
TL;DR: A novel regiospecific copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides on solid-phase is reported, and the X-ray structure of 2-azido-2-methylpropanoic acid has been solved, to yield structural information on the 1, 3-dipoles entering the reaction.
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Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
TL;DR: The bioorthogonal chemical reactions developed to date are described and how they can be used to study biomolecules.
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Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
TL;DR: The copper-catalyzed cycloaddition reaction between azides and alkynes functions efficiently in aqueous solution in the presence of a tris(triazolyl)amine ligand to make rapid and reliable covalent connections to micromolar concentrations of protein decorated with either of the reactive moieties.