Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4−/− mice
Martin Roderfeld,Timo Rath,Robert Voswinckel,Christian Dierkes,Hartmut Dietrich,Daniel Zahner,Jürgen Graf,Elke Roeb +7 more
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TLDR
The present study is the first to identify that both BM‐derived fibrocytes and HSC are involved in biliary fibrogenesis in Abcb4−/− mice, and suggests that changes in immunity subsequent to BM‐Tx may alter hepatic fibrosis.About:
This article is published in Hepatology.The article was published on 2010-01-01 and is currently open access. It has received 75 citations till now. The article focuses on the topics: Liver function & Hepatic stellate cell.read more
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Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis
Henning W. Zimmermann,S Seidler,Jacob Nattermann,Nikolaus Gassler,Claus Hellerbrand,Alma Zernecke,Jens J. W. Tischendorf,Tom Luedde,Ralf Weiskirchen,Christian Trautwein,Frank Tacke +10 more
TL;DR: The expansion of CD14+CD16+ monocytes in the circulation and liver of CLD-patients upon disease progression is demonstrated and their functional contribution to the perpetuation of intrahepatic inflammation and profibrogenic HSC activation in liver cirrhosis is suggested.
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Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches
TL;DR: Key events are the activation and transformation of quiescent hepatic stellate cells into myofibroblast-like cells with the subsequent up-regulation of proteins such as α-smooth muscle actin, interstitial collagens, matrix metalloproteinases, tissue inhibitor of metallofiltration, and proteoglycans.
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Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice
D. Scholten,D. Scholten,Christoph H. Österreicher,Anjali Scholten,Keiko Iwaisako,Guoqiang Gu,David A. Brenner,Tatiana Kisseleva +7 more
TL;DR: EMT of cholangiocytes identified by genetic labeling does not contribute to hepatic fibrosis in mice, providing no evidence for MET in HSCs in response to fibrogenic liver injury.
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Current status of novel antifibrotic therapies in patients with chronic liver disease
TL;DR: The advances in the elucidation of the biology of fibrosis, combined with improved technologies for assessment will provide a comprehensive framework for design of antifibrotics and their analysis in well-designed clinical trials, and may ultimately yield success in halting the progression of, or reversing, liver fibrosis.
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Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques.
Frank Tacke,Ralf Weiskirchen +1 more
TL;DR: Novel isolation techniques, specifically HSC sorting by FACS via autofluorescence and antibodies, will provide further opportunities to advance the understanding of HSC biology in health and disease.
References
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A new mathematical model for relative quantification in real-time RT-PCR.
TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.
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Histological grading and staging of chronic hepatitis.
Kamal G. Ishak,Amelia Baptista,Leonardo Bianchi,Francesco Callea,Jan De Groote,Fred Gudat,Helmut Denk,Valeer Desmet,Gerhard Korb,R. N. M. Macsween,M. James Phillips,Bernard G. Portmann,H. Poulsen,Peter J. Scheuer,Martin Schmid,Heribert Thaler +15 more
TL;DR: This research presents a meta-analysis of Anatomia e Istologia Patologica, a large quantity of which has never before been published in a peer-reviewed journal, which aims to provide real-time information about the immune system’s response to disease.
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Green mice' as a source of ubiquitous green cells
TL;DR: Transgenic mouse lines with an ‘enhanced’ GFP (EGFP) cDNA under the control of a chicken beta‐actin promoter and cytomegalovirus enhancer were produced and all of the tissues from these transgenic lines, with the exception of erythrocytes and hair, were green under excitation light.
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Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Eric Lagasse,Heather Connors,Muhsen Al-Dhalimy,Michael J. Reitsma,Monika Dohse,Linda Osborne,Xin Wang,Milton J. Finegold,Irving L. Weissman,Markus Grompe +9 more
TL;DR: It is reported that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver.
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Cell fusion is the principal source of bone-marrow-derived hepatocytes
Xin Wang,Holger Willenbring,Yassmine Akkari,Yumi Torimaru,Mark Foster,Muhsen Al-Dhalimy,Eric Lagasse,Milton J. Finegold,Susan B. Olson,Markus Grompe +9 more
TL;DR: It is concluded that hepatocytes derived form bone marrow arise from cell fusion and not by differentiation of haematopoietic stem cells.