Bone regeneration from mesenchymal stem cells (MSCs) and compact bone-derived MSCs as an animal model
Eiki Yamachika,Seiji Iida +1 more
TLDR
Mesenchymal stem cells have emerged as a promising alternative to traditional surgical techniques and attempts have been made to develop defined serum-free media for animal and human MSC growth; however, most products have demonstrated only limited performance.About:
This article is published in Japanese Dental Science Review.The article was published on 2013-02-01 and is currently open access. It has received 17 citations till now. The article focuses on the topics: Bone regeneration & Mesenchymal stem cell.read more
Citations
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Journal ArticleDOI
Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate
Thomas R.J. Heathman,Alexandra Stolzing,Alexandra Stolzing,Claire Fabian,Claire Fabian,Qasim A. Rafiq,Qasim A. Rafiq,Karen Coopman,Alvin W. Nienow,Alvin W. Nienow,Alvin W. Nienow,Bo Kara,Christopher J. Hewitt,Christopher J. Hewitt +13 more
TL;DR: It is demonstrated that HPL, compared with FBS-containing medium, delivers increased growth and comparability across two BM-hMSC donors between monolayer and microcarrier culture, which will have key implications for process transfer during scale-up.
Journal ArticleDOI
PCL/β-TCP Composite Scaffolds Exhibit Positive Osteogenic Differentiation with Mechanical Stimulation.
So Hee Park,Su A Park,Yun Gyeong Kang,Ji Won Shin,Young Shik Park,Seo Rin Gu,Yan Ru Wu,Jie Wei,Jung-Woog Shin +8 more
TL;DR: It is found that mechanical stimulation and the addition ofβ-TCP interacted closely, and that a mass fraction of β- TCP of 30% was particularly useful as a bone tissue scaffold when accompanied by mechanical stimulation.
Journal ArticleDOI
Cell-based bone regeneration for alveolar ridge augmentation--cell source, endogenous cell recruitment and immunomodulatory function.
TL;DR: If the authors were able to control the mobilization of endogenous osteoprogenitor cells, large-scale surgery may no longer be necessary and such treatment strategy may open a new era of safer and more effective alveolar ridge augmentation treatment options.
Dissertation
Multiscale femtosecond laser surface texturing of titanium and titanium alloys for dental and orthopaedic implants
TL;DR: In this paper, the surface texturing of Ti alloys using femtosecond laser direct writing method is explored as a potential technique to enhance the wettability of dental and orthopaedic implants by biological fluids and matrix mineralisation (bone formation), while reducing bacteria adhesion and biofilmformation.
Book ChapterDOI
Bioreactor-Based Bone Tissue Engineering
TL;DR: The optimization of protocols for bone graft production using autologous mesenchymal stem cells loaded on appropriate scaffolds, exposed to osteogenic inducers and mechanical force in bioreactor should be able to solve the current limitations in managing bone injuries.
References
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Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
Journal ArticleDOI
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
Journal ArticleDOI
Pluripotency of mesenchymal stem cells derived from adult marrow
Yuehua Jiang,Balkrishna N. Jahagirdar,R. Lee Reinhardt,Robert E. Schwartz,C. Dirk Keene,Xilma R. Ortiz-Gonzalez,Morayma Reyes,Todd Lenvik,Troy C. Lund,Mark Blackstad,Jingbo Du,Sara Aldrich,Aaron Lisberg,Walter C. Low,David A. Largaespada,Catherine M. Verfaillie +15 more
TL;DR: It is reported here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into meschymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro.
Journal ArticleDOI
Mesenchymal stem cells in health and disease
TL;DR: The targets and mechanisms of M SC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches are discussed.