Journal ArticleDOI
Boolean formalization of genetic control circuits
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TLDR
This paper is an attempt to formalize in Boolean terms genetic situations, from simple concepts like recessitivity and cis-dominance, to models describing complex control circuits, to describe in compact and unambiguous way, systems which become more and more difficult to describe as their complexity is being unravelled.About:
This article is published in Journal of Theoretical Biology.The article was published on 1973-12-01. It has received 986 citations till now. The article focuses on the topics: Expression (mathematics) & Binary function.read more
Citations
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Proceedings ArticleDOI
State Space Exploration of Spatially Organized Populations of Agents
TL;DR: This paper sketches the modeling framework and its semantics and shows how IRN may be used for the modeling of a population of simple agents, the automatic analysis of various reach ability properties and the use of symmetries to reduce the size of the state space.
Book ChapterDOI
Critical Delays in Logical Asynchronous Models
A. Verhamme,P. Van Ham +1 more
TL;DR: This work describes the kinetic logic formalization of a model as a complementary tool to the classical continuous formalism which is more limited in the number of state variables it can handle and is very sensitive to the nonlinear character of the kinetic differential equations.
Dissertation
Etude de la dynamique des mécanismes de la répression catabolique : des modèles mathématiques aux données expérimentales
TL;DR: In this paper, the authors propose an approche mathematique and experimentale for separer and evaluer l'importance of different mecanismes of the repression catabolique.
Journal ArticleDOI
Biocircuits in plants and eukaryotic algae
TL;DR: It is envisioned that the modulatory structural feature and the possibility of finer gene regulation through biocircuits can contribute to the complex design of synthetic chromosomes aiming to develop plants and algae with new or improved functions.
Posted Content
On the complexity of acyclic modules in automata networks
TL;DR: This paper provides results that offer an upper bound on the number of attractors in an acyclic module when wired recursively into an automata network, alongside a diversity of complexity results around the difficulty of deciding the existence of cycles depending on theNumber of inputs and the size of said cycle.
References
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Journal ArticleDOI
Genetic regulatory mechanisms in the synthesis of proteins.
François Jacob,Jacques Monod +1 more
TL;DR: The synthesis of enzymes in bacteria follows a double genetic control, which appears to operate directly at the level of the synthesis by the gene of a shortlived intermediate, or messenger, which becomes associated with the ribosomes where protein synthesis takes place.
Journal ArticleDOI
Metabolic stability and epigenesis in randomly constructed genetic nets
TL;DR: The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”.
Journal ArticleDOI
INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI. ANALYSIS OF MAINTENANCE
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The Novick-Weiner effect and the one to be analyzed here prove to be aspects of the same situation and a heterogeneity with respect to the induced synthesis of ,B-galactosidase simulating genetic differences could be provoked within a growing population of otherwise identical cells.
Journal ArticleDOI
ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The kinetics of induction of the galactozymase of certain yeasts and the permease-3-galactosidase system of Escherichia coli can, under certain conditions, be described as autocatalytic.
Journal ArticleDOI
Functional analysis of chemical systems in vivo using a logical circuit equivalent. II. The idea of a molecular automaton
TL;DR: The theory presented by the author in his previous paper in this journal, which concerned the use of logical circuits or symbolic logic, is revised and extended and the idea of a molecular automaton is introduced.
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Metabolic stability and epigenesis in randomly constructed genetic nets
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