Journal ArticleDOI
Boolean formalization of genetic control circuits
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TLDR
This paper is an attempt to formalize in Boolean terms genetic situations, from simple concepts like recessitivity and cis-dominance, to models describing complex control circuits, to describe in compact and unambiguous way, systems which become more and more difficult to describe as their complexity is being unravelled.About:
This article is published in Journal of Theoretical Biology.The article was published on 1973-12-01. It has received 986 citations till now. The article focuses on the topics: Expression (mathematics) & Binary function.read more
Citations
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Journal ArticleDOI
BDD-Based Algorithm for SCC Decomposition of Edge-Coloured Graphs
TL;DR: In this article , the authors propose a novel algorithm that symbolically computes all the monochromatic strongly connected components of an edge-colored graph, and evaluate the algorithm using an experimental implementation based on binary decision diagrams (BDDs).
Dissertation
Algorithmes pour la prédiction de stratégies de reprogrammation cellulaire dans les réseaux Booléens.
TL;DR: Cette these explique ce qu'est la reprogrammation cellulaire dans le cadre des reseaux Booleens, and quelles sont differentes methodes pour obtenir des solutions a ce probleme, ainsi profiter de the dynamique du reseau Booleen entre les perturbations.
Posted Content
On the cost of simulating a parallel Boolean automata network by a block-sequential one
TL;DR: In this article, the minimum number of additional automata that a Boolean automata network associated with a given block-sequential update schedule needs in order to simulate a given BAN with a parallel update schedule was studied.
Posted ContentDOI
The CoLoMoTo Interactive Notebook: Accessible and Reproducible Computational Analyses for Qualitative Biological Networks
Aurélien Naldi,Céline Hernandez,Nicolas Levy,Gautier Stoll,Pedro T. Monteiro,Claudine Chaouiya,Tomáš Helikar,Andrei Zinovyev,Laurence Calzone,Sarah Cohen-Boulakia,Denis Thieffry,Loïc Paulevé +11 more
TL;DR: A Python interface for each of the software tools including GINsim, BioLQM, Pint, MaBoSS, and Cell Collective is developed to offer a seamless integration in the Jupyter web interface and ease the chaining of complementary analyses.
Journal ArticleDOI
Boolean modeling of mechanosensitive epithelial to mesenchymal transition and its reversal
TL;DR: In this paper , a Boolean model of EMT triggered by mechanosensing is proposed to model the effects of biomechanical environment on cancer cell stemness linked to the hybrid E/M state, as well as the mutually inhibitory crosstalk between EMT and senescence.
References
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Journal ArticleDOI
Genetic regulatory mechanisms in the synthesis of proteins.
François Jacob,Jacques Monod +1 more
TL;DR: The synthesis of enzymes in bacteria follows a double genetic control, which appears to operate directly at the level of the synthesis by the gene of a shortlived intermediate, or messenger, which becomes associated with the ribosomes where protein synthesis takes place.
Journal ArticleDOI
Metabolic stability and epigenesis in randomly constructed genetic nets
TL;DR: The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”.
Journal ArticleDOI
INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI. ANALYSIS OF MAINTENANCE
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The Novick-Weiner effect and the one to be analyzed here prove to be aspects of the same situation and a heterogeneity with respect to the induced synthesis of ,B-galactosidase simulating genetic differences could be provoked within a growing population of otherwise identical cells.
Journal ArticleDOI
ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The kinetics of induction of the galactozymase of certain yeasts and the permease-3-galactosidase system of Escherichia coli can, under certain conditions, be described as autocatalytic.
Journal ArticleDOI
Functional analysis of chemical systems in vivo using a logical circuit equivalent. II. The idea of a molecular automaton
TL;DR: The theory presented by the author in his previous paper in this journal, which concerned the use of logical circuits or symbolic logic, is revised and extended and the idea of a molecular automaton is introduced.
Related Papers (5)
Metabolic stability and epigenesis in randomly constructed genetic nets
The logical analysis of continuous, non-linear biochemical control networks.
Leon Glass,Stuart A. Kauffman +1 more