Journal ArticleDOI
Boolean formalization of genetic control circuits
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TLDR
This paper is an attempt to formalize in Boolean terms genetic situations, from simple concepts like recessitivity and cis-dominance, to models describing complex control circuits, to describe in compact and unambiguous way, systems which become more and more difficult to describe as their complexity is being unravelled.About:
This article is published in Journal of Theoretical Biology.The article was published on 1973-12-01. It has received 986 citations till now. The article focuses on the topics: Expression (mathematics) & Binary function.read more
Citations
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Hybrid Simulations of Heterogeneous Biochemical Models in SBML
TL;DR: This article shows how two SBML reaction models can be composed into one hybrid continuous--stochastic SBML model through a high-level interface for composing reaction models and specifying their interpretation, and describes dynamic strategies for automatically partitioning reactions with stochastic or continuous interpretations according to dynamic criteria.
Journal ArticleDOI
A simple computational cell: Coupling boolean gene and protein networks
TL;DR: An abstract, tunable model containing two of the principal information-processing features of cells is presented and its use with simulated evolution is explored.
Dissertation
Modélisation stochastique de systèmes biologiques multi-échelles et inhomogènes en espace
TL;DR: In this article, Crudu, Debussche, Muller et Radulescu et al. presented a set of conditions d'approximations deterministes par des solutions d'equations d'evolution (type reaction-advection-diffusion).
Journal ArticleDOI
Formal modeling and analysis of ER-α associated Biological Regulatory Network in breast cancer.
TL;DR: Results suggest that the increased expressions of receptors ER-α, IGF-1R and EGFR slow down the activity of tumor suppressor genes (TSGs) such as BRCA1, p53 and Mdm2 which can lead to metastasis in BC.
Journal ArticleDOI
Geometric analysis of pathways dynamics: Application to versatility of TGF-β receptors.
Satya Swarup Samal,Aurélien Naldi,Dima Grigoriev,Andreas Weber,Nathalie Théret,Ovidiu Radulescu +5 more
TL;DR: Using expression data from the NCI60 panel of human tumor cell lines, it is shown that aggressive and non-aggressive tumour cell lines function in different metastable regimes and can be distinguished by measuring the relative concentrations of receptors of the two types.
References
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Journal ArticleDOI
Genetic regulatory mechanisms in the synthesis of proteins.
François Jacob,Jacques Monod +1 more
TL;DR: The synthesis of enzymes in bacteria follows a double genetic control, which appears to operate directly at the level of the synthesis by the gene of a shortlived intermediate, or messenger, which becomes associated with the ribosomes where protein synthesis takes place.
Journal ArticleDOI
Metabolic stability and epigenesis in randomly constructed genetic nets
TL;DR: The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”.
Journal ArticleDOI
INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI. ANALYSIS OF MAINTENANCE
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The Novick-Weiner effect and the one to be analyzed here prove to be aspects of the same situation and a heterogeneity with respect to the induced synthesis of ,B-galactosidase simulating genetic differences could be provoked within a growing population of otherwise identical cells.
Journal ArticleDOI
ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The kinetics of induction of the galactozymase of certain yeasts and the permease-3-galactosidase system of Escherichia coli can, under certain conditions, be described as autocatalytic.
Journal ArticleDOI
Functional analysis of chemical systems in vivo using a logical circuit equivalent. II. The idea of a molecular automaton
TL;DR: The theory presented by the author in his previous paper in this journal, which concerned the use of logical circuits or symbolic logic, is revised and extended and the idea of a molecular automaton is introduced.
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Metabolic stability and epigenesis in randomly constructed genetic nets
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