Journal ArticleDOI
Boolean formalization of genetic control circuits
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TLDR
This paper is an attempt to formalize in Boolean terms genetic situations, from simple concepts like recessitivity and cis-dominance, to models describing complex control circuits, to describe in compact and unambiguous way, systems which become more and more difficult to describe as their complexity is being unravelled.About:
This article is published in Journal of Theoretical Biology.The article was published on 1973-12-01. It has received 986 citations till now. The article focuses on the topics: Expression (mathematics) & Binary function.read more
Citations
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Principles of dynamical modularity in biological regulatory networks
Dávid Deritei,William C. Aird,Mária Ercsey-Ravasz,Erzsébet Ravasz Regan,Erzsébet Ravasz Regan +4 more
TL;DR: This work argues that distinct phenotype-combinations are generated by interactions among robust regulatory switches, each in control of a discrete set of phenotypic outcomes, and demonstrates the advantage of characterizing multi-switch regulatory systems in terms of their constituent switches by building a multiswitch cell cycle model.
Journal ArticleDOI
Mathematical formalisms based on approximated kinetic representations for modeling genetic and metabolic pathways
TL;DR: Current SC, (log)linear and Lin-log models have less specific methods available to estimate parameter values than the power- law formalism, which implies that more information is needed to parameterize SC models.
Journal ArticleDOI
An adjustable aperiodic model class of genomic interactions using continuous time Boolean networks (Boolean delay equations)
TL;DR: This paper incorporates a biologically motivated refractory period into the dynamic behavior of continuous-time Boolean networks, which exhibit binary values like traditional Boolean Networks, but which, unlike Boolean network, evolve in continuous time.
Journal ArticleDOI
On the basic computational structure of gene regulatory networks
TL;DR: A comparative study of Escherichia coli, Bacillus subtilis and Saccharomyces cerevisiae gene regulatory networks extracts the minimal core of causal relations, uncovering the hierarchical and modular organisation from a novel dynamical/causal perspective.
Journal ArticleDOI
Detection of attractors of large Boolean networks via exhaustive enumeration of appropriate subspaces of the state space
TL;DR: lnet is a software package that facilitates the analysis of large Boolean networks with up to 150 nodes and a good part of any present cycles and provides standard Boolean analysis features such as node loop detection.
References
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Journal ArticleDOI
Genetic regulatory mechanisms in the synthesis of proteins.
François Jacob,Jacques Monod +1 more
TL;DR: The synthesis of enzymes in bacteria follows a double genetic control, which appears to operate directly at the level of the synthesis by the gene of a shortlived intermediate, or messenger, which becomes associated with the ribosomes where protein synthesis takes place.
Journal ArticleDOI
Metabolic stability and epigenesis in randomly constructed genetic nets
TL;DR: The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”.
Journal ArticleDOI
INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI. ANALYSIS OF MAINTENANCE
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The Novick-Weiner effect and the one to be analyzed here prove to be aspects of the same situation and a heterogeneity with respect to the induced synthesis of ,B-galactosidase simulating genetic differences could be provoked within a growing population of otherwise identical cells.
Journal ArticleDOI
ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The kinetics of induction of the galactozymase of certain yeasts and the permease-3-galactosidase system of Escherichia coli can, under certain conditions, be described as autocatalytic.
Journal ArticleDOI
Functional analysis of chemical systems in vivo using a logical circuit equivalent. II. The idea of a molecular automaton
TL;DR: The theory presented by the author in his previous paper in this journal, which concerned the use of logical circuits or symbolic logic, is revised and extended and the idea of a molecular automaton is introduced.
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Metabolic stability and epigenesis in randomly constructed genetic nets
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