Journal ArticleDOI
Boolean formalization of genetic control circuits
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TLDR
This paper is an attempt to formalize in Boolean terms genetic situations, from simple concepts like recessitivity and cis-dominance, to models describing complex control circuits, to describe in compact and unambiguous way, systems which become more and more difficult to describe as their complexity is being unravelled.About:
This article is published in Journal of Theoretical Biology.The article was published on 1973-12-01. It has received 986 citations till now. The article focuses on the topics: Expression (mathematics) & Binary function.read more
Citations
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Journal ArticleDOI
Analyse qualitative de la dynamique de réseaux de régulation génique par des modèles linéaires par morceaux
Gregory Batt,Hidde de Jong,Johannes Geiselmann,Jean-Luc Gouzé,Michel Page,Delphine Ropers,Tewfik Sari,Dominique Schneider +7 more
TL;DR: This review discusses a method for the qualitative modeling and simulation of genetic regulatory networks which is well-adapted to the current lack of precise and quantitative biological data and describes a discrete abstraction underlying this method.
Journal ArticleDOI
NSRGRN: a network structure refinement method for gene regulatory network inference
TL;DR: Zhang et al. as mentioned in this paper proposed a network structure refinement method for gene regulatory networks (NSRGRN) that effectively combines the topological properties and edge importance measures during GRN inference.
Posted ContentDOI
Advances in the integration of transcriptional regulatory information into genome-scale metabolic models
R.P. Vivek-Ananth,Areejit Samal +1 more
TL;DR: Here, a review of the existing methods to integrate transcriptional regulatory information into constraint-based models of metabolic networks in order to increase the predictive capabilities of computational models and understand the regulation of cellular metabolism.
Proceedings ArticleDOI
Verification of multistability in gene regulation networks: A combinatorial approach
Christian Breindl,Frank Allgöwer +1 more
TL;DR: This work considers gene regulation networks with known interaction structure but unknown reaction kinetics, and considers each operation mode as a forward-invariant set in the state space and with the notion of compatible intervals how the validation problem can be translated into a combinatorial one.
Posted Content
On the Stability of Conjunctive Boolean Networks
TL;DR: This paper develops a method that decomposes the wiring diagram into a number of components each of which is an irreducible subgraph, and shows that the stability of conjunctive Boolean networks may switch from one limit cycle to another under certain conditions.
References
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Journal ArticleDOI
Genetic regulatory mechanisms in the synthesis of proteins.
François Jacob,Jacques Monod +1 more
TL;DR: The synthesis of enzymes in bacteria follows a double genetic control, which appears to operate directly at the level of the synthesis by the gene of a shortlived intermediate, or messenger, which becomes associated with the ribosomes where protein synthesis takes place.
Journal ArticleDOI
Metabolic stability and epigenesis in randomly constructed genetic nets
TL;DR: The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”.
Journal ArticleDOI
INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI. ANALYSIS OF MAINTENANCE
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The Novick-Weiner effect and the one to be analyzed here prove to be aspects of the same situation and a heterogeneity with respect to the induced synthesis of ,B-galactosidase simulating genetic differences could be provoked within a growing population of otherwise identical cells.
Journal ArticleDOI
ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The kinetics of induction of the galactozymase of certain yeasts and the permease-3-galactosidase system of Escherichia coli can, under certain conditions, be described as autocatalytic.
Journal ArticleDOI
Functional analysis of chemical systems in vivo using a logical circuit equivalent. II. The idea of a molecular automaton
TL;DR: The theory presented by the author in his previous paper in this journal, which concerned the use of logical circuits or symbolic logic, is revised and extended and the idea of a molecular automaton is introduced.
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Metabolic stability and epigenesis in randomly constructed genetic nets
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