Journal ArticleDOI
Boolean formalization of genetic control circuits
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TLDR
This paper is an attempt to formalize in Boolean terms genetic situations, from simple concepts like recessitivity and cis-dominance, to models describing complex control circuits, to describe in compact and unambiguous way, systems which become more and more difficult to describe as their complexity is being unravelled.About:
This article is published in Journal of Theoretical Biology.The article was published on 1973-12-01. It has received 986 citations till now. The article focuses on the topics: Expression (mathematics) & Binary function.read more
Citations
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Abstracting Asynchronous Multi-Valued Networks: An Initial Investigation
TL;DR: In this article, the authors develop an abstraction theory for asynchronous multi-valued network models, which allows the state space of a model to be reduced while preserving key properties of the model.
Journal ArticleDOI
On the flora of asynchronous locally non-monotonic Boolean automata networks
TL;DR: In this article, a general characterisation of the asynchronous transition graphs of strongly connected and non-monotonic BANs is given, where all the local transition functions are ⊕-functions.
Proceedings Article
Model Revision of Logical Regulatory Networks Using Logic-Based Tools.
TL;DR: This work intends to obtain a model building procedure capable of providing the modeler with repaired models satisfying a set of pre-defined criteria, therefore minimizing possible modeling errors.
Patent
Synthetic mammalian neuromuscular junction and method of screening for a candidate drug thereon
James J. Hickman,Xiufang Guo +1 more
TL;DR: In this paper, a method for forming neuromuscular junctions between motoneurons and muscle cells was proposed, which involves co-culturing one or more human motoneuron and one/more human muscle cells in a substantially serum-free medium.
Journal ArticleDOI
Computational Complexity of Minimal Trap Spaces in Boolean Networks
TL;DR: In this paper , the complexity of the trap space property of a sub-hypercube, the minimality, and the membership of a given configuration to a minimal trap space are investigated.
References
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Journal ArticleDOI
Genetic regulatory mechanisms in the synthesis of proteins.
François Jacob,Jacques Monod +1 more
TL;DR: The synthesis of enzymes in bacteria follows a double genetic control, which appears to operate directly at the level of the synthesis by the gene of a shortlived intermediate, or messenger, which becomes associated with the ribosomes where protein synthesis takes place.
Journal ArticleDOI
Metabolic stability and epigenesis in randomly constructed genetic nets
TL;DR: The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”.
Journal ArticleDOI
INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI. ANALYSIS OF MAINTENANCE
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The Novick-Weiner effect and the one to be analyzed here prove to be aspects of the same situation and a heterogeneity with respect to the induced synthesis of ,B-galactosidase simulating genetic differences could be provoked within a growing population of otherwise identical cells.
Journal ArticleDOI
ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS
Melvin Cohn,Kengo Horibata +1 more
TL;DR: The kinetics of induction of the galactozymase of certain yeasts and the permease-3-galactosidase system of Escherichia coli can, under certain conditions, be described as autocatalytic.
Journal ArticleDOI
Functional analysis of chemical systems in vivo using a logical circuit equivalent. II. The idea of a molecular automaton
TL;DR: The theory presented by the author in his previous paper in this journal, which concerned the use of logical circuits or symbolic logic, is revised and extended and the idea of a molecular automaton is introduced.
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