Journal ArticleDOI
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
TLDR
The biological machinery used by brain tumour stem cells to commandeer tissues in the intracranial space, evade immune responses and resist chemoradiotherapy is reviewed.About:
This article is published in Nature Reviews Cancer.The article was published on 2022-06-16. It has received 21 citations till now. The article focuses on the topics: Medicine & Biology.read more
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Nanoparticles for Drug and Gene Delivery in Pediatric Brain Tumors’ Cancer Stem Cells: Current Knowledge and Future Perspectives
Luana Abballe,Zaira Spinello,Celeste Antonacci,Lucia Coppola,Ermanno Miele,Giuseppina Catanzaro,Evelina Miele +6 more
TL;DR: In this paper , a review of nanoparticle-based approaches for the treatment of brain tumor is presented, together with recent advances in nanoparticle design/synthesis with the final aim to specifically target the insidious CSCs population in the tumor bulk.
Journal ArticleDOI
Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization
Aryeh Silver,Diana Feier,Tanya Ghosh,Maryam Rahman,Jianping Huang,Matthew R. Sarkisian,Loic P. Deleyrolle +6 more
TL;DR: The diversity of CSC lineages present in GBM and how this glioma stem cell (GSC) mosaicism drives global intratumoral heterogeneity constituted by complex and spatially distinct local microenvironments is reviewed.
Journal ArticleDOI
Protein Kinase D1 Signaling in Cancer Stem Cells with Epithelial-Mesenchymal Plasticity
Yichen Guo,Yinan Jiang,J. Bart Rose,Ganji Purnachandra Nagaraju,Renata Jaskula-Sztul,Anita B. Hjelmeland,Adam W. Beck,Herbert Chen,Bin Ren +8 more
TL;DR: In this paper , the authors demonstrate that CSCs in human pNETs co-express protein kinase PKD1 and CD44, and further identify PKD-1 signaling as a critical pathway in the control of CSC maintenance in pNET cells.
Journal ArticleDOI
The Cytotoxic Effects of Cannabidiol and Cannabigerol on Glioblastoma Stem Cells May Mostly Involve GPR55 and TRPV1 Signalling
Tamara T. Lah,Bernarda Majc,Metka Novak,Ajda Sušnik,Barbara Breznik,Andrej Porčnik,Roman Bošnjak,Aleksander Sadikov,M. Malavolta,Selma Halilčević,Jernej Mlakar,Roby Zomer +11 more
TL;DR: In this article , the authors proposed that GPR55 and TRPV1 receptors are the best targets for the antagonistic cannabinoids CBD and CBG (in an optimized mixture) to eliminate GBM stem cells.
Journal ArticleDOI
New insights into the Immune TME of adult-type diffuse gliomas
TL;DR: In this paper , a comprehensive dissection of the intratumoral ecosystem of human gliomas using single-cell and spatial transcriptomic approaches is presented, which supports the prognostic value of tumorassociated macrophages and microglial cells, and sheds light on novel therapeutic options.
References
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Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.
Quinn T. Ostrom,Haley Gittleman,Peter Liao,Chaturia Rouse,Yanwen Chen,Jacqueline Dowling,Yingli Wolinsky,Carol Kruchko,Jill S. Barnholtz-Sloan +8 more
TL;DR: The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the US.
Journal ArticleDOI
Identification of human brain tumour initiating cells
Sheila K. Singh,Cynthia Hawkins,Ian D. Clarke,Jeremy A. Squire,Jane Bayani,Takuichiro Hide,R. Mark Henkelman,Michael D. Cusimano,Peter B. Dirks +8 more
TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
Journal ArticleDOI
The clonal evolution of tumor cell populations
TL;DR: Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
Journal ArticleDOI
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao,Qiulian Wu,Roger E. McLendon,Yueling Hao,Qing Ming Shi,Anita B. Hjelmeland,Mark W. Dewhirst,Darell D. Bigner,Jeremy N. Rich +8 more
TL;DR: This work shows that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity, and suggests that CD133-positive tumour cells could be the source of tumour recurrence after radiation.
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