Journal ArticleDOI
Brain-derived neurotrophic factor and early-life stress: Multifaceted interplay.
TLDR
This mini-review focuses on the structure and regulation of the Bbnf gene as well as on the stress–BDNF interactions under early-life adverse conditions.Abstract:
The brain-derived neurotrophic factor (BDNF) is a key regulator of neural development and plasticity. Long-term changes in the BDNF pathway are associated with childhood adversity and adult depression symptoms. Initially, stress-induced decreases in the BDNF pathway were found in some studies, but subsequent reports indicated the relationship between stress and BDNF to be much more complex, and the concept was significantly revised. In the present mini-review, we focus on the structure and regulation of the Bbnf gene as well as on the stress–BDNF interactions under early-life adverse conditions.read more
Citations
More filters
Journal ArticleDOI
Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects.
TL;DR: The hypothesis that brief separation of pups from their mothers (handling), which can be considered as moderate stress, may result in future positive changes in behavior is supported.
Journal ArticleDOI
The connection between microbiome and schizophrenia.
Bogdana Golofast,Karel Vales +1 more
TL;DR: This article aims to describe and understand the developmental relationships between intestinal microbiota and the risk of developing schizophrenia.
Journal ArticleDOI
Stress early in life leads to cognitive impairments, reduced numbers of CA3 neurons and altered maternal behavior in adult female mice.
Vasiliy V. Reshetnikov,Anna V. Kovner,Arina A. Lepeshko,Arina A. Lepeshko,Konstantin S. Pavlov,Larisa N. Grinkevich,Natalya P. Bondar,Natalya P. Bondar +7 more
TL;DR: The results suggest that prolonged MS early in life affects the adult behavior of F0 female mice and hippocampal neuronal plasticity, whereas the mothers' previous experience has effects on the behavior of their F1 offspring through disturbances of mother‐infant interactions.
Journal ArticleDOI
A cross-sectional study of fatty acids and brain-derived neurotrophic factor (BDNF) in human milk from lactating women following vegan, vegetarian, and omnivore diets.
TL;DR: Breast milk from vegans had significantly higher unsaturated fat and total omega-3 fats, and lower saturated fats, trans fats,and omega-6 to omega- 3 ratios than their vegetarian and omnivore counterparts.
Journal ArticleDOI
Epigenetics: A missing link between early life stress and depression
TL;DR: Advances in knowledge of epigenetics in the context of early life stress and depression provide a new understanding of the genetic influence on psychopathology and could lead to the identification of new targets for clinical intervention.
References
More filters
Journal ArticleDOI
Neurotrophins: roles in neuronal development and function.
Eric J. Huang,Louis F. Reichardt +1 more
TL;DR: Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems, and control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival.
Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
TL;DR: Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.
Journal ArticleDOI
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
TL;DR: It is demonstrated that BDNF and NT-3 are stress-responsive genes and the possibility that alterations in the expression of these or other growth factors might be important in producing some of the physiological and pathophysiological effects of stress in the hippocampus is raised.
Journal ArticleDOI
Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
Journal ArticleDOI
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Anita E. Autry,Lisa M. Monteggia +1 more
TL;DR: Clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases is provided.