Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans
Maria Chondronikola,Elena Volpi,Elisabet Børsheim,Elisabet Børsheim,Craig Porter,Craig Porter,Manish Kumar Saraf,Manish Kumar Saraf,Palam Annamalai,Christina Yfanti,Christina Yfanti,Tony Chao,Tony Chao,Daniel Wong,Kosaku Shinoda,Sebastien M. Labbė,Nicholas M. Hurren,Nicholas M. Hurren,Fernardo Cesani,Shingo Kajimura,Labros S. Sidossis +20 more
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TLDR
The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.About:
This article is published in Cell Metabolism.The article was published on 2016-06-14 and is currently open access. It has received 243 citations till now. The article focuses on the topics: Brown adipose tissue & White adipose tissue.read more
Citations
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Journal ArticleDOI
Adipose tissue in control of metabolism
Liping Luo,Meilian Liu +1 more
TL;DR: This review will summarize the recent findings of adipose tissue in the control of metabolism, focusing on its endocrine and thermogenic function.
Journal ArticleDOI
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
Takeshi Yoneshiro,Qiang Wang,Kazuki Tajima,Mami Matsushita,Hiroko Maki,Kaori Igarashi,Zhipeng Dai,Phillip J. White,Robert W. McGarrah,Olga Ilkayeva,Yann Deleye,Yasuo Oguri,Mito Kuroda,Kenji Ikeda,Huixia Li,Ayano Ueno,Maki Ohishi,Takamasa Ishikawa,Kyeongkyu Kim,Yong Chen,Carlos H.G. Sponton,Rachana N. Pradhan,Homa Majd,Vanille J. Greiner,Momoko Yoneshiro,Zachary Brown,Maria Chondronikola,Haruya Takahashi,Tsuyoshi Goto,Teruo Kawada,Labros S. Sidossis,Francis C. Szoka,Michael T. McManus,Masayuki Saito,Tomoyoshi Soga,Shingo Kajimura +35 more
TL;DR: It is reported that, on cold exposure, brown adipose tissue (BAT) actively utilizes BCAA in the mitochondria for thermogenesis and promotes systemic BCAA clearance in mice and humans and suggests that BAT serves as a key metabolic filter that controls BCAA cleared via SLC25A44, thereby contributing to the improvement of metabolic health.
Journal ArticleDOI
Brown adipose tissue is associated with cardiometabolic health
Tobias Becher,Tobias Becher,Srikanth Palanisamy,Srikanth Palanisamy,Daniel J. Kramer,Daniel J. Kramer,Daniel J. Kramer,Mahmoud Eljalby,Mahmoud Eljalby,Sarah J. Marx,Andreas Wibmer,Scott D. Butler,Caroline S. Jiang,Roger D. Vaughan,Roger D. Vaughan,Heiko Schöder,Allyn L. Mark,Paul Cohen +17 more
TL;DR: In this article, the authors reported that individuals with BAT had lower prevalences of cardiometabolic diseases, and the presence of BAT was independently correlated with lower odds of type 2 diabetes, dyslipidemia, coronary artery disease, cerebrovascular disease, congestive heart failure and hypertension.
Journal ArticleDOI
Brown adipose tissue energy metabolism in humans
André C. Carpentier,Denis P. Blondin,Kirsi A. Virtanen,Denis Richard,François Haman,Eric Turcotte +5 more
TL;DR: A comprehensive review of metabolically active brown adipose tissue (BAT) in humans primarily using positron emission tomography coupled to computed tomography (PET/CT) with the glucose tracer 18-fluorodeoxyglucose (18FDG) is offered.
Journal ArticleDOI
Metabolic adaptation and maladaptation in adipose tissue
TL;DR: The current understanding of adipocyte metabolism in physiology and metabolic disease is reviewed, and strategies to reprogram adipocyte fate and metabolism are discussed, including possible strategies to alter fuel utilization in fat cells to improve metabolic health.
References
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Journal ArticleDOI
Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Journal ArticleDOI
Cold-activated brown adipose tissue in healthy men.
Wouter D. van Marken Lichtenbelt,Joost W. Vanhommerig,Nanda M Smulders,Jamie Drossaerts,Gerrit J. Kemerink,Nicole D. Bouvy,Patrick Schrauwen,G J Jaap Teule +7 more
TL;DR: Brown adipose tissue may be metabolically important in men, and the fact that it is reduced yet present in most overweight or obese subjects may make it a target for the treatment of obesity.
Journal ArticleDOI
Functional brown adipose tissue in healthy adults.
Kirsi A. Virtanen,Martin E. Lidell,Janne Orava,Mikael Heglind,Rickard Westergren,Tarja Niemi,Markku Taittonen,Jukka Laine,Nina-Johanna Savisto,Sven Enerbäck,Pirjo Nuutila +10 more
TL;DR: These findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
Journal ArticleDOI
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
D. F. S. Rolfe,Guy C. Brown +1 more
TL;DR: The differences in standard metabolic rate between animals of different body mass and phylogeny appear to be due to proportionate changes in the whole of energy metabolism.
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Alexander Bartelt,Oliver T. Bruns,Rudolph Reimer,Heinz Hohenberg,Harald Ittrich,Kersten Peldschus,Michael G. Kaul,Ulrich I. Tromsdorf,Horst Weller,Christian Waurisch,Alexander Eychmüller,Philip L.S.M. Gordts,F. Rinninger,Karoline Bruegelmann,Barbara Freund,Peter Nielsen,Martin Merkel,Joerg Heeren +17 more