Journal ArticleDOI
Cadmium stress: an oxidative challenge
Ann Cuypers,Michelle Plusquin,Tony Remans,Marijke Jozefczak,Els Keunen,Heidi Gielen,Kelly Opdenakker,Ambily Ravindran Nair,Elke Munters,Tom Artois,Tim S. Nawrot,Jaco Vangronsveld,Kelly Smeets +12 more
TLDR
The current review gives an overview on Cd-induced ROS production and anti-oxidative defense in organisms under different Cd regimes and the C d-induced oxidative challenge is discussed with a focus on damage and signaling as downstream responses.Abstract:
At the cellular level, cadmium (Cd) induces both damaging and repair processes in which the cellular redox status plays a crucial role. Being not redox-active, Cd is unable to generate reactive oxygen species (ROS) directly, but Cd-induced oxidative stress is a common phenomenon observed in multiple studies. The current review gives an overview on Cd-induced ROS production and anti-oxidative defense in organisms under different Cd regimes. Moreover, the Cd-induced oxidative challenge is discussed with a focus on damage and signaling as downstream responses. Gathering these data, it was clear that oxidative stress related responses are affected during Cd stress, but the apparent discrepancies observed in between the different studies points towards the necessity to increase our knowledge on the spatial and temporal ROS signature under Cd stress. This information is essential in order to reveal the exact role of Cd-induced oxidative stress in the modulation of downstream responses under a diverse array of conditions.read more
Citations
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Advances in metal-induced oxidative stress and human disease
Klaudia Jomová,Marian Valko +1 more
TL;DR: An overview of redox and non-redox metal-induced formation of free radicals and the role of oxidative stress in toxic action of metals is provided.
Book
Heavy metals in soils : trace metals and metalloids in soils and their bioavailability
TL;DR: In this article, the authors defined the sources of heavy metals and metalloids in Soils and derived methods for the determination of Heavy Metals and Metalloids in soil.
Journal ArticleDOI
Unravelling cadmium toxicity and tolerance in plants: Insight into regulatory mechanisms
Susana M. Gallego,Susana M. Gallego,Liliana B. Pena,Liliana B. Pena,Roberto A. Barcia,Claudia E. Azpilicueta,María Florencia Iannone,María Florencia Iannone,Eliana Paola Rosales,Eliana Paola Rosales,Myriam Sara Zawoznik,María Daniela Groppa,María Daniela Groppa,Maria Patricia Benavides,Maria Patricia Benavides +14 more
TL;DR: This article reviews current knowledge of uptake, transport and accumulation of Cd in plants and gives an overview of C d-detoxification mechanisms, Cd-induced oxidative damage and antioxidant defenses in plants, and presents a picture of the role of reactive oxygen and nitrogen species in Cd toxicity.
Journal ArticleDOI
The Effects of Cadmium Toxicity
Giuseppe Genchi,Maria Stefania Sinicropi,Graziantonio Lauria,Alessia Carocci,Alessia Catalano +4 more
TL;DR: Recent studies show that cadmium induces various epigenetic changes in mammalian cells, both in vivo and in vitro, causing pathogenic risks and the development of various types of cancers.
Journal ArticleDOI
Redox- and non-redox-metal-induced formation of free radicals and their role in human disease.
TL;DR: Current views regarding the role of redox-active/inactive metal-induced formation of ROS, modifications to biomolecules in human disease such as cancer, cardiovascular disease, metabolic disease, Alzheimer's disease, Parkinson’s disease, renal disease, blood disorders and other disease are summarized.
References
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Journal ArticleDOI
ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control
Graham Noctor,Christine H. Foyer +1 more
TL;DR: A detailed account of current knowledge of the biosynthesis, compartmentation, and transport of these two important antioxidants, with emphasis on the unique insights and advances gained by molecular exploration are provided.
Journal ArticleDOI
Reactive oxygen gene network of plants
TL;DR: In Arabidopsis, a network of at least 152 genes is involved in managing the level of ROS, and this network is highly dynamic and redundant, and encodes ROS-scavenging and ROS-producing proteins.
Journal ArticleDOI
Oxidative stress: oxidants and antioxidants
TL;DR: These low molecular mass antioxidant molecules add significantly to the defense provided by the enzymes superoxide dismutase, catalase and glutathione peroxidases, which are termed ‘oxidative stress’.
Journal ArticleDOI
Metals, toxicity and oxidative stress.
TL;DR: This review summarizes recent findings in the metal-induced formation of free radicals and the role of oxidative stress in the carcinogenicity and toxicity of metals.
Journal ArticleDOI
Oxidative mechanisms in the toxicity of metal ions
Sidney J. Stohs,Debasis Bagchi +1 more
TL;DR: Some mechanisms associated with the toxicities of metal ions are very similar to the effects produced by many organic xenobiotics, related to differences in solubilities, absorbability, transport, chemical reactions, and the complexes that are formed within the body.