Journal ArticleDOI
Calbindin‐D28k, calretinin, and recovering immunoreactivities in developing chick pineal gland
Enrico Bastianelli,Roland Pochet +1 more
TLDR
Calbindin‐D28k, calretinin, and recover in immunoreactivities in developing chick pineal gland are studied in immunofiltration and recovery studies.Abstract:
Calbindin-D28k, calretinin, and recoverin, three intracellular calcium-binding proteins belonging to the troponin C/calmodulin superfamily, were immunohistochemically localized in chick pineal during development [from embryonic day 16 (E16) to postnatal day 14 (P14)]. At E18, only calretinin immunoreactivity could be detected in nuclei from follicular pinealocytes. With development, calretinin immunoreactivity expanded from nucleus to cytoplasm, and calretinin immuno-positive cell number increased. At P14 almost al pinealocytes were calretinin positive. Calbindin-D28k immunoreactivity was not detected before E20. During development, many follicular and parafollicular pinealocytes became strongly calbindin-D28k positive, reaching a peak both in intensity and in number at P7; thereafter their number decreased. In addition to pinealocytes, neuron-like cells appeared calbindin-D28k positive at E20 and calretinin positive at P7. Recoverin, a myristoylated protein isolated from vertebrate photoreceptor and which might participate in the inactivation of the phototransduction cascade, was transiently expressed in follicular and parafollicular pinealocytes from P1 to P14 with a maximal expression at P7. This transitory expression may coincide with a transitory light sensitivity period in chick pinealocytes, before complete maturity of the pineal gland.read more
Citations
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Journal ArticleDOI
Cellular circadian clocks in the pineal.
TL;DR: This review focuses on the functional properties of the cellular circadian clocks of non-mammalian vertebrates and how functions the clock?
Journal ArticleDOI
Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function
TL;DR: This review focuses on calcium-dependent membrane association by the so-called calcium-myristoyl switch as a possible mechanism of signal transduction and on the roles of NCS proteins in intraneuronal signaling cascades, which are best studied in the visual and olfactory systems.
Journal ArticleDOI
Nonvisual photoreceptors of the deep brain, pineal organs and retina.
Béla Vigh,M. J. Manzano,A Zádori,C. L. Frank,Ákos Lukáts,Pál Röhlich,Ágoston Szél,Csaba Dávid +7 more
TL;DR: Experimental and molecular aspects are discussed, focusing on the histological and histochemical basis of the function of nonvisual photoreceptors, and a view about functional changes of these photoreCEPTors during pre- and postnatal development as well as about its possible evolution are offered.
Journal ArticleDOI
The 2004 Aschoff/Pittendrigh lecture: Theory of the origin of the pineal gland--a tale of conflict and resolution.
TL;DR: The hypothesis argues that early in chordate evolution, at a point before the genes required for melatonin synthesis were acquired, retinaldehyde—which is essential for photon capture—was depleted by reacting with naturally occurring arylalkylamines and xenobiotic aries, resulting in the formation of adducts analogous to formation in the retina of the toxic bis-retinyl ethanolamine (A2E).
Book ChapterDOI
Ca2+-dependent control of rhodopsin phosphorylation: recoverin and rhodopsin kinase.
TL;DR: The present review considers recoverin, rhodopsin kinase and their interrelationships in the in vitro as well as in vivo contexts and identifies the leading candidate for the role of an intracellular target for recoverin.
References
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Journal ArticleDOI
Calbindin D-28k and parvalbumin in the rat nervous system
TL;DR: The distribution of structures stained with mono- and polyclonal antibodies to the calcium-binding proteins calbindin D-28k and parvalbumin in the nervous system of adult rats is described and it can be stated that cal bindin antibodies mainly label cells with thin, unmyelinated axons projecting in a diffuse manner.
Journal ArticleDOI
Calcium-binding proteins in the nervous system.
TL;DR: Among the many calcium-binding proteins in the nervous system, parvalbumin, calbindin-D28K and calretinin are particularly striking in their abundance and in the specificity of their distribution.
Journal ArticleDOI
Calcium regulation of the neuronal growth cone.
TL;DR: Ca 2+ may act as a common integrator of environmental cues that influence neurite outgrowth and synaptogenesis, and in this way may play a key role in the establishment and modulation of brain circuitry.
Journal ArticleDOI
Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase.
Alexander M. Dizhoor,Sanghamitra Ray,Santosh Kumar,Greg Niemi,Maribeth Spencer,Doane Brolley,Kenneth A. Walsh,Paul P. Philipov,James B. Hurley,Lubert Stryer +9 more
TL;DR: Vertebrate retinal photoreceptors recover from photoexcitation-induced hydrolysis of guanosine 3', 5'-monophosphate (cyclic GMP) by resynthesizing cyclicGMP, which reopens cation channels that have been closed by light.
Journal ArticleDOI
Calretinin in rat brain: an immunohistochemical study.
Anne Résibois,John H. Rogers +1 more
TL;DR: The pattern of calretinin immunoreactivity in the rat brain is described, which includes some distinctive positive structures whose identity is uncertain, notably irregular "shells" of cells and fibres around the thalamus and in the amygdala and an unnamed cell type in the vestibulocerebellum.