Journal ArticleDOI
Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior.
TLDR
New insights on the contribution of material properties towards osteoinductivity and the role of signaling molecules involved in osteoblastic differentiation can potentially aid the design of CPC-based biomaterials that support bone regeneration without the need for additional biochemical supplements.About:
This article is published in Acta Biomaterialia.The article was published on 2013-09-01. It has received 615 citations till now. The article focuses on the topics: Bone regeneration.read more
Citations
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Journal ArticleDOI
Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications.
Noam Eliaz,Noah Metoki +1 more
TL;DR: A wide variety of CaPs are presented, from the individual phases to nano-CaP, biphasic and triphasic CaP formulations, composite CaP coatings and cements, functionally graded materials (FGMs), and antibacterial CaPs.
Journal ArticleDOI
Bioactive calcium phosphate materials and applications in bone regeneration
TL;DR: Calcium phosphate has been utilized to improve bone regeneration in ways such as increasing osteoconductivity for bone ingrowth, enhancing osteoinductivity in combination with various healing agents, and encapsulating drugs or growth factors.
Journal ArticleDOI
Osteoinduction of bone grafting materials for bone repair and regeneration.
TL;DR: The overall objective of this paper is to gather the current knowledge on osteoinductivity of bone grafting materials for the effective development of new graft substitutes that enhance bone regeneration.
Journal ArticleDOI
3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy.
TL;DR: 3D-printed bioceramic scaffolds with different compositions and hierarchical structures (macro, micro, and nano scales), and their effects on the mechanical, degradation, permeability, and biological properties are focused on.
Journal ArticleDOI
Osteoblast differentiation and bone matrix formation in vivo and in vitro
Harry C. Blair,Quitterie C. Larrouture,Yanan Li,Hang Lin,Donna Beer-Stoltz,Li Liu,Rocky S. Tuan,Lisa J. Robinson,Paul H. Schlesinger,Deborah J. Nelson +9 more
TL;DR: The characteristics of osteoblast differentiation and bone matrix synthesis are reviewed, which reveal a sophisticated proton export network driving mineralization, a gene expression program organized with the compartmentalization of the osteooblast epithelium that produces the mature bone matrix composite, despite varying serum calcium and phosphate.
References
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Journal ArticleDOI
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Kazuhisa Nakashima,Xin Zhou,Gary R. Kunkel,Zhaoping Zhang,Jian Min Deng,Richard R. Behringer,Benoit de Crombrugghe +6 more
TL;DR: It is proposed that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells, because Osx null preostEoblasts express typical chondrocyte marker genes, and Osx acts downstream of Runx 2/C bfa1.
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Biological and medical significance of calcium phosphates.
TL;DR: Calcium phosphates have a great biological and medical significance and in this review, an overview of the current knowledge in this subject is given.
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Osteoinduction, osteoconduction and osseointegration.
TL;DR: Osseointegration is the stable anchorage of an implant achieved by direct bone-to-implant contact in craniofacial implantology and this mode of anchorage is the only one for which high success rates have been reported.
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Calcium phosphate-based osteoinductive materials.
TL;DR: This review focuses on calcium phosphate-based bone substitute materials that are used (or can be used) for teeth or bone replacement, bone repair, augmentation, or regeneration and will also include some properties of bone (e.g., interconnected porosity, biodegradability, bioactivity, osteoconductivity) that are being mimicked in the manufacture of calcium phosphates.
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Calcium phosphates as substitution of bone tissues
TL;DR: In this paper, a review of the role played by biological calcium phosphates in bone regeneration is presented, where the synthesis procedures to obtain in the laboratory calcium deficient carbonate nanoapatite both in bulk and thin film forms, as well as the characterization methods applied to these materials are described.