Journal ArticleDOI
Calmodulin activates NAD kinase of sea urchin eggs: an early event of fertilization.
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TLDR
In vitro and in vivo studies indicate that calmodulin is part of the linkage between the rise in Ca2+ at fertilization and the turning on of egg metabolism.About:
This article is published in Cell.The article was published on 1981-02-01. It has received 169 citations till now. The article focuses on the topics: Calmodulin & NAD+ kinase.read more
Citations
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The role of protein phosphorylation in neural and hormonal control of cellular activity
TL;DR: There is an integrated network of regulatory pathways, mediated by phosphorylation–dephosphorylation, that allows diverse cellular events to be coordinated by neural and hormonal stimuli, and the evidence that supports this concept is reviewed.
Journal ArticleDOI
The power to reduce: pyridine nucleotides – small molecules with a multitude of functions
TL;DR: Recent advances in the understanding of the biosynthesis and signalling functions of NAD(P) are summarized and new insights into the molecular mechanisms of NADPH generation and their roles in cell physiology are highlighted.
Journal ArticleDOI
Changes of free calcium levels with stages of the cell division cycle
TL;DR: In addition to the known transient rise of [Ca2+]i at fertilization, further peaks are now revealed during pronuclear migration, nuclear envelope breakdown, the metaphase/anaphase transition and cleavage.
Journal ArticleDOI
A Derivative of NADP Mobilizes Calcium Stores Insensitive to Inositol Trisphosphate and Cyclic ADP-ribose (∗)
Hon Cheung Lee,Robert Aarhus +1 more
TL;DR: The NAADP-dependent Ca release showed desensitization and was insensitive to heparin and a specific antagonist of cyclic ADP-ribose ( cADPR), 8-amino-cADPR, indicating the NAADp-dependent mechanism is operative in intact cells.
Journal ArticleDOI
Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
TL;DR: The role of the Ca2+-mobilizing messenger NAADP (nicotinic acid adenine dinucleotide phosphate) as a major regulator of Ca2+, and the recent discovery of an endolysosomal channel family, the TPCs (two-pore channels), as its principal intracellular targets are discussed.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Calmodulin plays a pivotal role in cellular regulation
TL;DR: The role of calcium ions (Ca2+) in cell function is beginning to be unraveled at the molecular level as a result of recent research on calcium-binding proteins and particularly on calmodulin.
Journal ArticleDOI
Regulation and Kinetics of the Actin-Myosin-ATP Interaction
R S Adelstein,E Eisenberg +1 more
Journal ArticleDOI
Calmodulin—an intracellular calcium receptor
Anthony R. Means,John R. Dedman +1 more
TL;DR: Calmodulin, a protein that binds calcium with high affinity and specificity, is structurally conserved and functionally preserved throughout the animal and plant kingdoms.
Related Papers (5)
Intracellular Calcium Release at Fertilization in the Sea Urchin Egg
Direct measurement of intracellular pH during metabolic derepression of the sea urchin egg.
Intracellular pH and activation of sea urchin eggs after fertilisation.
James D. Johnson,David Epel +1 more