Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders.
María Salud García-Gutiérrez,Francisco Navarrete,Francisco Navarrete,Ani Gasparyan,Ani Gasparyan,Amaya Austrich-Olivares,Francisco Sala,Jorge Manzanares,Jorge Manzanares +8 more
- Vol. 10, Iss: 11, pp 1575
TLDR
Preliminary clinical trials support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant, and more importantly, a positive risk-benefit profile, and support the development of large-scale studies to further evaluate CBD as a potential new drug for the treatment of these psychiatric disorders.Abstract:
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting great interest, especially for managing neuropsychiatric disorders due to the relative lack of efficacy of the current treatments. Numerous studies have been carried out using the main phytocannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD displays an interesting pharmacological profile without the potential for becoming a drug of abuse, unlike THC. In this review, we focused on the anxiolytic, antidepressant, and antipsychotic effects of CBD found in animal and human studies. In rodents, results suggest that the effects of CBD depend on the dose, the strain, the administration time course (acute vs. chronic), and the route of administration. In addition, certain key targets have been related with these CBD pharmacological actions, including cannabinoid receptors (CB1r and CB2r), 5-HT1A receptor and neurogenesis factors. Preliminary clinical trials also support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant, and more importantly, a positive risk-benefit profile. These promising results support the development of large-scale studies to further evaluate CBD as a potential new drug for the treatment of these psychiatric disorders.read more
Citations
More filters
Journal ArticleDOI
Citrus limon L. (lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing the sleep duration.
Md. Mominur Rahman,Fahadul Islam,Anwar Parvez,Md. Abul Kashem Azad,Ghulam Md Ashraf,M.F. Ullah,Muniruddin Ahmed +6 more
TL;DR: In this paper , the phytochemical compounds and neuropharmacological potential of the seed extract of Citrus limon as a step to partially validate its formulations as nutraceuticals using an in vivo model.
Journal ArticleDOI
Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis
Fahadul Islam,Saikat Mitra,Mohamed H Nafady,Mohammad Tauhidur Rahman,Vineet Tirth,Aklima Akter,Talha Bin Emran,Amany Abdel-Rahman Mohamed,Ali Algahtani,Sanad S El-Kholy +9 more
TL;DR: The findings showed that L. coromandelica has potential neuropharmacological effects and leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research.
Journal ArticleDOI
Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain.
Barbara Stella,Francesca Baratta,Carlo Della Pepa,Silvia Arpicco,Daniela Gastaldi,Franco Dosio +5 more
TL;DR: The most recent results from pharmaceutical companies and research groups investigating methods to improve cannabinoid bioavailability and to clearly establish its therapeutic efficacy, dose ranges, safety and also improve the patient compliance are presented in this article.
Journal ArticleDOI
Delivering therapeutic cannabinoids via skin: Current state and future perspectives.
TL;DR: In this paper, the feasibility of delivering therapeutic cannabinoids via skin and providing a comprehensive account of the supporting research studies that have been reported in the literature till date is discussed. And emerging topical and transdermal strategies could be exploited for the successful development of highly effective delivery systems for cannabinoids.
Journal ArticleDOI
Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People.
Lyndsey L. Anderson,Peter T. Doohan,Lachlan D. Oldfield,Richard C. Kevin,Jonathon C. Arnold,Maximus Berger,G. Paul Amminger,Iain S. McGregor +7 more
TL;DR: In this paper, the effect of CBD on CYP450-mediated metabolism of the commonly used antidepressants fluoxetine, sertraline, citalopram, and mirtazapine were examined in vitro.
References
More filters
Journal ArticleDOI
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
William A. Devane,Lumir Hanus,Aviva Breuer,Roger G. Pertwee,Lesley A. Stevenson,Graeme Griffin,Dan Gibson,Asher Mandelbaum,A. Etinger,Raphael Mechoulam +9 more
TL;DR: In this article, an arachidonylethanthanolamide (anandamide) was identified in a screen for endogenous ligands for the cannabinoid receptor and its structure was determined by mass spectrometry and nuclear magnetic resonance spectroscopy and confirmed by synthesis.
Journal ArticleDOI
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Y. Gaoni,Raphael Mechoulam +1 more
TL;DR: In this paper, the extinction coefficients of stilbene, stil bene-, and stilben-2 were determined for tetrahydrofuran, 2-methyltetrahydrlfurfh-fragments, and 1,2-dime thoxye thane.
Journal ArticleDOI
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
TL;DR: Overall, the CMS procedure appears to be at least as valid as any other animal model of depression, and can be used to study problems that are extremely difficult to address by other means.
Journal ArticleDOI
Psychological autopsy studies of suicide: a systematic review.
TL;DR: In this paper, a systematic review aimed to examine the results of studies of suicide that used a psychological autopsy method, which offers the most direct technique currently available for examining the relationship between particular antecedents and suicide.
Journal Article
Psychological autopsy studies of suicide: a systematic review. (vol 33, pg 395, 2003)
TL;DR: The results indicated that mental disorder was the most strongly associated variable of those that have been studied and suicide prevention strategies may be most effective if focused on the treatment of mental disorders.