Journal ArticleDOI
Capillary innervation in the mammalian central nervous system: an electron microscopic demonstration.
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Capillaries in the cat hypothalamus receive axon terminals which are comparable to neurovascular junctions in cerebral and systemic arteries and arterioles, in contrast to cerebral arterial vessels, which are supplied by the peripheral autonomic nervous system.Abstract:
Capillaries in the cat hypothalamus receive axon terminals which are comparable to neurovascular junctions in cerebral and systemic arteries and arterioles. The innervation of capillaries in the central nervous system may be derived from central neurons, in contrast to cerebral arterial vessels, which are supplied by the peripheral autonomic nervous system.read more
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Evidence for a ‘Paravascular’ fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
TL;DR: HRP enters the neuraxis along the intraparenchymal microvasculature far more rapidly than can be explained on this basis, and it is postulate that a fluid circulation through the CNS occurs via paravascular pathways.
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Cerebral vessels in ageing and Alzheimer's disease
TL;DR: Brain imaging and permeability studies show no clear functional evidence to support the structural and biochemical anomalies, but it is plausible that focal and transient breach of the blood-brain barrier in ageing, and more notably in AD, occurs.
Journal ArticleDOI
Serotonin in the regulation of brain microcirculation
TL;DR: The cerebral circulation has full capacity to adequately and locally adapt brain perfusion to changes in central 5-HT neurotransmission either directly or indirectly via the neuronal-astrocytic-vascular tripartite functional unit.
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Barrier mechanisms for neurotransmitter monoamines and their precursors at the blood‐brain interface
Jan Erik Hardebo,Christer Owman +1 more
TL;DR: The integrity of the endothelial cell lining of the cerebrovascular bed constitutes a morphological blood‐brain barrier mechanism to neurotransmitter monoamines, and the use of decarboxylase and monoamine oxidase inhibitors as adjuncts to L‐dopa treatment of Parkinson disease is suggested.
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Physiology and pharmacological role of the blood-brain barrier.
TL;DR: The blood-brain barrier is the most significant element responsible for the preservation of CNS homeostasis and can be investigated as a functional system as a frontier composed of pericytes, astrocytic end feet, and brain endothelial cells (ECs).
References
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The Use of Dopamine β-Hydroxylase as a Marker for the Central Noradrenergic Nervous System in Rat Brain
TL;DR: Improvements in the method for localization of dopamine-beta-hydroxylase by immunofluorescence allow the observation of noradrenergic-cell bodies, non-terminal fibers, and axon terminals in the rat brain, and these observations suggest that cerebral microcirculation is regulated by central nor adrenergic neurons.
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Adrenergic innervation of pial arteries related to the circle of Willis in the cat
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Electron Microscopic Identification of Autonomic Nerve Endings
TL;DR: Care must be taken in fixing tissues containing adrenergic axons to avoid severe losses of catecholamines by diffusion or extraction, and some doubt has been cast on the reliability of granular vesicles as an index of adrenergic function.