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Journal ArticleDOI

Cardiac Resynchronization in Chronic Heart Failure

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TLDR
Cardiac resynchronization results in significant clinical improvement in patients who have moderate-to-severe heart failure and an intraventricular conduction delay.
Abstract
Background Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a double-blind trial to evaluate this therapeutic approach. Methods Four hundred fifty-three patients with moderate-to-severe symptoms of heart failure associated with an ejection fraction of 35 percent or less and a QRS interval of 130 msec or more were randomly assigned to a cardiac-resynchronization group (228 patients) or to a control group (225 patients) for six months, while conventional therapy for heart failure was maintained. The primary end points were the New York Heart Association functional class, quality of life, and the distance walked in six minutes. Results As compared with the control group, patients assigned to cardiac resynchronization experienced an improvement in the distance walked in six minutes (+39 vs. +10 m, P=0.005), functional clas...

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Journal ArticleDOI

The effect of cardiac resynchronization on morbidity and mortality in heart failure

TL;DR: Cardiac resynchronization has been shown to reduce symptoms and improve left ventricular function in patients with heart failure due to systolic dysfunction and cardiac dyssynchrony.
References
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Journal ArticleDOI

Reversal of Left Ventricular Remodeling by Synchronous Biventricular Pacing in Heart Failure

TL;DR: Synchronous biventricular pacing for 3 months was associated with hemodynamic improvements, reversal of left ventricular remodeling, and increase inleft ventricular systolic function, and a decrease in secondary mitral regurgitation.
Journal Article

Long-term prognosis of patients presenting to the emergency room with decompensated congestive heart failure.

TL;DR: It is confirmed that the long term prognosis of patients needing hospitalization for congestive heart failure remains poor and readily available acute-phase clinical variables may assist in predicting prognosis.
Journal ArticleDOI

Reduction of hospital days by biventricular pacing

TL;DR: Biventricular pacing improved 13/16 patients with severe heart failure and wide QRS complexes in this open study and resulted in a reduced need for hospital care.
Journal ArticleDOI

Evaluation of left ventricular function and mitral regurgitation during left ventricular-based pacing in patients with heart failure.

TL;DR: Beneficial effects of left ventricular (LV)‐based pacing on acute hemodynamic parameters were reported in several series, but only a few studies examined the long‐term effects of this new pacing procedure.
Journal ArticleDOI

Adverse events with transvenous left ventricular pacing in patients with severe heart failure: early experience from a single centre.

TL;DR: Placement of a permanent lead in a tributary of the coronary sinus is feasible without serious adverse effects during the first month and the only frequent adverse event was lead dislodgement; a finding which emphasizes the need for development of specially designed leads for this application.
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