Journal ArticleDOI
Cardiac Resynchronization in Chronic Heart Failure
William T. Abraham,Westby G. Fisher,Andrew L. Smith,David B. Delurgio,Angel R. Leon,Evan Loh,Dusan Z. Kocovic,Milton Packer,Alfredo L. Clavell,David L. Hayes,Myrvin H. Ellestad,Robin J. Trupp,Jackie Underwood,Faith Pickering,Cindy Truex,Peggy McAtee,John C. Messenger +16 more
Reads0
Chats0
TLDR
Cardiac resynchronization results in significant clinical improvement in patients who have moderate-to-severe heart failure and an intraventricular conduction delay.Abstract:
Background Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a double-blind trial to evaluate this therapeutic approach. Methods Four hundred fifty-three patients with moderate-to-severe symptoms of heart failure associated with an ejection fraction of 35 percent or less and a QRS interval of 130 msec or more were randomly assigned to a cardiac-resynchronization group (228 patients) or to a control group (225 patients) for six months, while conventional therapy for heart failure was maintained. The primary end points were the New York Heart Association functional class, quality of life, and the distance walked in six minutes. Results As compared with the control group, patients assigned to cardiac resynchronization experienced an improvement in the distance walked in six minutes (+39 vs. +10 m, P=0.005), functional clas...read more
Citations
More filters
Journal ArticleDOI
Invasive acute hemodynamic response to guide left ventricular lead implantation predicts chronic remodeling in patients undergoing cardiac resynchronization therapy.
Simon G. Duckett,Simon G. Duckett,Matthew Ginks,Matthew Ginks,Anoop Shetty,Anoop Shetty,Julian Bostock,Jaswinder Gill,Shoaib Hamid,Stam Kapetanakis,Eliane Cunliffe,Reza Razavi,Reza Razavi,Gerry Carr-White,C. Aldo Rinaldi,C. Aldo Rinaldi +15 more
TL;DR: Using AHR to guide LV lead positioning and improve response rates is useful for predicting which patients are likely to remodel in response to CRT both for dilated cardiomyopathy and ischemic carduomyopathy.
Journal ArticleDOI
Left Ventricular Versus Simultaneous Biventricular Pacing in Patients With Heart Failure and a QRS Complex ≥120 Milliseconds
Bernard Thibault,Anique Ducharme,François Harel,Michel White,Eileen O'Meara,Marie-Claude Guertin,Joel Lavoie,Nancy Frasure-Smith,Marc Dubuc,Peter G. Guerra,Laurent Macle,Lena Rivard,Denis Roy,Mario Talajic,Paul Khairy +14 more
TL;DR: LV pacing is not superior to biventricular pacing, however, nonresponders to BiV pacing may respond favorably to LV pacing, suggesting a potential role as tiered therapy.
Journal ArticleDOI
Cardiac resynchronisation for patients with heart failure due to left ventricular systolic dysfunction — a systematic review and meta‐analysis
Nick Freemantle,Puvan Tharmanathan,Melanie Calvert,William T. Abraham,Justin Ghosh,John G.F. Cleland +5 more
TL;DR: The objective was to provide a valid synthesis of the effects of CRT on mortality, major morbidity, quality of life and implantation success rates.
Journal ArticleDOI
Effect of posterolateral left ventricular scar on mortality and morbidity following cardiac resynchronization therapy.
Shajil Chalil,Berthold Stegemann,S. A. Muhyaldeen,Kayvan Khadjooi,Paul W X Foley,Russell E A Smith,Francisco Leyva +6 more
TL;DR: The objective is to determine the effect of a posterolateral (PL) left ventricular scar on mortality and morbidity following cardiac resynchronization therapy (CRT).
Journal ArticleDOI
Upgrading from single chamber right ventricular to biventricular pacing in permanently paced patients with worsening heart failure: The RD-CHF Study.
Christophe Leclercq,Serge Cazeau,David Lellouche,Fabien Fossati,Fréderic Anselme,Jean-Marc Davy,Nicolas Sadoul,Didier Klug,Luca Mollo,F.E.S.C. Jean-Claude Daubert M.D. +9 more
TL;DR: This pilot, single‐blind, randomized, cross‐over study examined the safety and efficacy of upgrading conventional pacing systems to BiV stimulation in patients with advanced CHF.
References
More filters
Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal ArticleDOI
Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay
Serge Cazeau,Christophe Leclercq,Thomas Lavergne,S Walker,Varma C,Cecilia Linde,Stéphane Garrigue,Lukas Kappenberger,G A Haywood,Massimo Santini,Bailleul C,Jean-Claude Daubert,Multisite Stimulation in Cardiomyopathies (Mustic) Study Investigators +12 more
TL;DR: In this article, transvenous atriobiventricular pacemakers (with leads in one atrium and each ventricle) were used to reduce ventricular asynchrony.
Journal Article
The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure
Gordon H. Guyatt,Michael J. Sullivan,Penelope J. Thompson,Ernest L. Fallen,S. O. Pugsley,D W Taylor,Leslie B. Berman +6 more
TL;DR: It is concluded that the 6-minute walk is a useful measure of functional exercise capacity and a suitable measure of outcome for clinical trials in patients with chronic heart failure.
Journal ArticleDOI
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II
Bertram Pitt,Philip A. Poole-Wilson,Robert Segal,Felipe Martinez,Kenneth Dickstein,A. John Camm,Marvin A. Konstam,Günter A.J. Riegger,George Klinger,James D. Neaton,Divakar Sharma,Balasamy Thiyagarajan +11 more
TL;DR: The ELITE II Losartan Heart Failure Survival Study as discussed by the authors showed an association between the angiotensin II antagonist losartan and an unexpected survival benefit in elderly heart-failure patients, compared with captopril, an ACE inhibitor.