Journal ArticleDOI
Cardiac Resynchronization in Chronic Heart Failure
William T. Abraham,Westby G. Fisher,Andrew L. Smith,David B. Delurgio,Angel R. Leon,Evan Loh,Dusan Z. Kocovic,Milton Packer,Alfredo L. Clavell,David L. Hayes,Myrvin H. Ellestad,Robin J. Trupp,Jackie Underwood,Faith Pickering,Cindy Truex,Peggy McAtee,John C. Messenger +16 more
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TLDR
Cardiac resynchronization results in significant clinical improvement in patients who have moderate-to-severe heart failure and an intraventricular conduction delay.Abstract:
Background Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a double-blind trial to evaluate this therapeutic approach. Methods Four hundred fifty-three patients with moderate-to-severe symptoms of heart failure associated with an ejection fraction of 35 percent or less and a QRS interval of 130 msec or more were randomly assigned to a cardiac-resynchronization group (228 patients) or to a control group (225 patients) for six months, while conventional therapy for heart failure was maintained. The primary end points were the New York Heart Association functional class, quality of life, and the distance walked in six minutes. Results As compared with the control group, patients assigned to cardiac resynchronization experienced an improvement in the distance walked in six minutes (+39 vs. +10 m, P=0.005), functional clas...read more
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Journal ArticleDOI
Comparative assessment of right, left, and biventricular pacing in patients with permanent atrial fibrillation
Michele Brignole,Michael D. Gammage,Enrico Puggioni,Paolo Alboni,A. Raviele,Richard Sutton,Panos E. Vardas,Maria Grazia Bongiorni,Lennart Bergfeldt,Carlo Menozzi,Giacomo Musso +10 more
TL;DR: In this paper, a randomized, single-blind, 3-month crossover comparison between right ventricular apical pacing (RV) and left ventricular (LV) pacing (BiV) was performed in 56 patients with severely symptomatic permanent atrial fibrillation, uncontrolled ventricular rate, or heart failure.
Journal ArticleDOI
Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure
Martin Borggrefe,Thomas Lawo,Christian Butter,Herwig Schmidinger,Maurizio Lunati,Burkert Pieske,Anand R. Ramdat Misier,Antonio Curnis,Dirk Böcker,Andrew Remppis,Joseph Kautzner,Markus Stühlinger,Christophe Leclerq,Miloš Táborský,Maria Frigerio,Michael K. Parides,Daniel Burkhoff,Gerhard Hindricks +17 more
TL;DR: In patients with heart failure and left ventricular dysfunction, CCM signals appear safe; exercise tolerance and quality of life (MLWHFQ) were significantly better while patients were receiving active treatment with CCM for a 3-month period.
Journal ArticleDOI
Evidence of Structural Remodeling in the Dyssynchronous Failing Heart
Patrick A. Helm,Laurent Younes,Mirza Faisal Beg,Daniel B. Ennis,Christophe Leclercq,Owen P. Faris,Elliot R. McVeigh,David A. Kass,Michael I. Miller,Raimond L. Winslow +9 more
TL;DR: In this article, the geometry, fiber, and sheet architecture of eight normal and five dyssynchronous failing canine hearts, which were explanted and fixed in an unloaded state, were measured using diffusion tensor imaging.
Journal ArticleDOI
Clinical implications of new-onset left bundle branch block after transcatheter aortic valve replacement: analysis of the PARTNER experience.
Tamim Nazif,Mathew R. Williams,Rebecca T. Hahn,Samir R. Kapadia,Vasilis Babaliaros,Josep Rodes-Cabau,Wilson Y. Szeto,Hasan Jilaihawi,William F. Fearon,Danny Dvir,Todd M. Dewey,Raj Makkar,Ke Xu,Jose Dizon,Craig R. Smith,Martin B. Leon,Susheel Kodali +16 more
TL;DR: Persistent, new-onset LBBB was not associated with death, repeat hospitalization, stroke, or myocardial infarction at 1 year, but was associated with a higher rate of PPI and failure of left ventricular ejection fraction to improve.
Journal ArticleDOI
Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: a PROSPECT (Predictors of Response to CRT) sub-analysis
Rutger J. van Bommel,Jeroen J. Bax,William T. Abraham,Eugene S. Chung,Luis A. Pires,Luigi Tavazzi,Peter Zimetbaum,Bart Gerritse,Nina Kristiansen,Stefano Ghio +9 more
TL;DR: Sub-analysis of data from PROSPECT showed that gender, aetiology ofHF, QRS duration, severity of HF, a history of VT, and the presence of baseline mechanical dyssynchrony influence clinical and/or LV reverse remodelling after CRT.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal ArticleDOI
Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay
Serge Cazeau,Christophe Leclercq,Thomas Lavergne,S Walker,Varma C,Cecilia Linde,Stéphane Garrigue,Lukas Kappenberger,G A Haywood,Massimo Santini,Bailleul C,Jean-Claude Daubert,Multisite Stimulation in Cardiomyopathies (Mustic) Study Investigators +12 more
TL;DR: In this article, transvenous atriobiventricular pacemakers (with leads in one atrium and each ventricle) were used to reduce ventricular asynchrony.
Journal Article
The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure
Gordon H. Guyatt,Michael J. Sullivan,Penelope J. Thompson,Ernest L. Fallen,S. O. Pugsley,D W Taylor,Leslie B. Berman +6 more
TL;DR: It is concluded that the 6-minute walk is a useful measure of functional exercise capacity and a suitable measure of outcome for clinical trials in patients with chronic heart failure.
Journal ArticleDOI
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II
Bertram Pitt,Philip A. Poole-Wilson,Robert Segal,Felipe Martinez,Kenneth Dickstein,A. John Camm,Marvin A. Konstam,Günter A.J. Riegger,George Klinger,James D. Neaton,Divakar Sharma,Balasamy Thiyagarajan +11 more
TL;DR: The ELITE II Losartan Heart Failure Survival Study as discussed by the authors showed an association between the angiotensin II antagonist losartan and an unexpected survival benefit in elderly heart-failure patients, compared with captopril, an ACE inhibitor.