Journal ArticleDOI
Cardiac Resynchronization in Chronic Heart Failure
William T. Abraham,Westby G. Fisher,Andrew L. Smith,David B. Delurgio,Angel R. Leon,Evan Loh,Dusan Z. Kocovic,Milton Packer,Alfredo L. Clavell,David L. Hayes,Myrvin H. Ellestad,Robin J. Trupp,Jackie Underwood,Faith Pickering,Cindy Truex,Peggy McAtee,John C. Messenger +16 more
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TLDR
Cardiac resynchronization results in significant clinical improvement in patients who have moderate-to-severe heart failure and an intraventricular conduction delay.Abstract:
Background Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a double-blind trial to evaluate this therapeutic approach. Methods Four hundred fifty-three patients with moderate-to-severe symptoms of heart failure associated with an ejection fraction of 35 percent or less and a QRS interval of 130 msec or more were randomly assigned to a cardiac-resynchronization group (228 patients) or to a control group (225 patients) for six months, while conventional therapy for heart failure was maintained. The primary end points were the New York Heart Association functional class, quality of life, and the distance walked in six minutes. Results As compared with the control group, patients assigned to cardiac resynchronization experienced an improvement in the distance walked in six minutes (+39 vs. +10 m, P=0.005), functional clas...read more
Citations
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Journal ArticleDOI
Novel Speckle-Tracking Radial Strain From Routine Black-and-White Echocardiographic Images to Quantify Dyssynchrony and Predict Response to Cardiac Resynchronization Therapy
TL;DR: Speckle-tracking radial strain can quantify dyssynchrony and predict immediate and long-term response to CRT and has potential for clinical application.
Journal ArticleDOI
ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalities.
Andrew E. Epstein,John P. DiMarco,Kenneth A. Ellenbogen,N.A. Mark Estes,Roger A. Freedman,Leonard S. Gettes,A. Marc Gillinov,Gabriel Gregoratos,Stephen C. Hammill,David L. Hayes,Mark A. Hlatky,L. Kristin Newby,Richard L. Page,Mark H. Schoenfeld,Michael J. Silka,Lynne W. Stevenson,Michael O. Sweeney,Sidney C. Smith,Alice K. Jacobs,Cynthia D. Adams,Jeffrey L. Anderson,Christopher E. Buller,Mark A. Creager,Steven M. Ettinger,David P. Faxon,Jonathan L. Halperin,Loren F. Hiratzka,Sharon A. Hunt,Harlan M. Krumholz,Frederick G. Kushner,Bruce W. Lytle,Rick A. Nishimura,Joseph P. Ornato,Barbara Riegel,Lynn G. Tarkington,Clyde W. Yancy +35 more
TL;DR: The American College of Cardiology Foundation Board of Trustees in February 2008, document be cited as follows.
Journal ArticleDOI
Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials.
David J. Bradley,Elizabeth A. Bradley,Elizabeth A. Bradley,Kenneth L. Baughman,Kenneth L. Baughman,Ronald D. Berger,Hugh Calkins,Steven N. Goodman,David A. Kass,Neil R. Powe +9 more
TL;DR: In this paper, the authors conducted a meta-analysis of randomized controlled trials to determine whether cardiac resynchronization reduces mortality from progressive heart failure in patients with symptomatic left ventricular dysfunction.
Journal ArticleDOI
Cardiac-Resynchronization Therapy in Heart Failure with Narrow QRS Complexes
John F. Beshai,Richard A. Grimm,Sherif F. Nagueh,James H. Baker,Scott L. Beau,Steven M. Greenberg,Luis A. Pires,Patrick J. Tchou +7 more
TL;DR: CRT did not improve peak oxygen consumption in patients with moderate-to-severe heart failure, providing evidence that patients with heart failure and narrow QRS intervals may not benefit from CRT.
Journal ArticleDOI
ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices: Summary Article
Gabriel Gregoratos,Jonathan Abrams,Andrew E. Epstein,Roger A. Freedman,David L. Hayes,Mark A. Hlatky,Richard E. Kerber,Gerald V. Naccarelli,Mark H. Schoenfeld,Michael J. Silka,Stephen L. Winters,Raymond J. Gibbons,Elliott M. Antman,Joseph S. Alpert,Loren F. Hiratzka,David P. Faxon,Alice K. Jacobs,Valentin Fuster,Sidney C. Smith +18 more
TL;DR: The current update of the ACC/AHA/NASPE Guidelines for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices includes several significant changes in the recommendations and in the supporting narrative portion as mentioned in this paper.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal ArticleDOI
Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay
Serge Cazeau,Christophe Leclercq,Thomas Lavergne,S Walker,Varma C,Cecilia Linde,Stéphane Garrigue,Lukas Kappenberger,G A Haywood,Massimo Santini,Bailleul C,Jean-Claude Daubert,Multisite Stimulation in Cardiomyopathies (Mustic) Study Investigators +12 more
TL;DR: In this article, transvenous atriobiventricular pacemakers (with leads in one atrium and each ventricle) were used to reduce ventricular asynchrony.
Journal Article
The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure
Gordon H. Guyatt,Michael J. Sullivan,Penelope J. Thompson,Ernest L. Fallen,S. O. Pugsley,D W Taylor,Leslie B. Berman +6 more
TL;DR: It is concluded that the 6-minute walk is a useful measure of functional exercise capacity and a suitable measure of outcome for clinical trials in patients with chronic heart failure.
Journal ArticleDOI
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II
Bertram Pitt,Philip A. Poole-Wilson,Robert Segal,Felipe Martinez,Kenneth Dickstein,A. John Camm,Marvin A. Konstam,Günter A.J. Riegger,George Klinger,James D. Neaton,Divakar Sharma,Balasamy Thiyagarajan +11 more
TL;DR: The ELITE II Losartan Heart Failure Survival Study as discussed by the authors showed an association between the angiotensin II antagonist losartan and an unexpected survival benefit in elderly heart-failure patients, compared with captopril, an ACE inhibitor.