Journal ArticleDOI
Cardiac Resynchronization in Chronic Heart Failure
William T. Abraham,Westby G. Fisher,Andrew L. Smith,David B. Delurgio,Angel R. Leon,Evan Loh,Dusan Z. Kocovic,Milton Packer,Alfredo L. Clavell,David L. Hayes,Myrvin H. Ellestad,Robin J. Trupp,Jackie Underwood,Faith Pickering,Cindy Truex,Peggy McAtee,John C. Messenger +16 more
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TLDR
Cardiac resynchronization results in significant clinical improvement in patients who have moderate-to-severe heart failure and an intraventricular conduction delay.Abstract:
Background Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a double-blind trial to evaluate this therapeutic approach. Methods Four hundred fifty-three patients with moderate-to-severe symptoms of heart failure associated with an ejection fraction of 35 percent or less and a QRS interval of 130 msec or more were randomly assigned to a cardiac-resynchronization group (228 patients) or to a control group (225 patients) for six months, while conventional therapy for heart failure was maintained. The primary end points were the New York Heart Association functional class, quality of life, and the distance walked in six minutes. Results As compared with the control group, patients assigned to cardiac resynchronization experienced an improvement in the distance walked in six minutes (+39 vs. +10 m, P=0.005), functional clas...read more
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Journal ArticleDOI
The role of echocardiography in predicting responders to cardiac resynchronization therapy.
Yoshihiro Seo,Hiroshi Ito,Satoshi Nakatani,Mitsuaki Takami,Shigeto Naito,Tsuyoshi Shiga,Kenji Ando,Yuji Wakayama,Kazutaka Aonuma +8 more
TL;DR: No single echocardiographic criterion had significant power to detect volume responders, but a combining measurement of dyssynchrony between septum and LV free wall with M-mode and tissue Doppler imaging was independently associated with volume responders.
Journal ArticleDOI
Vectorcardiographic QRS area as a novel predictor of response to cardiac resynchronization therapy
Caroline J.M. van Deursen,Kevin Vernooy,Elton A. M. P. Dudink,Lennart Bergfeldt,Harry J.G.M. Crijns,Frits W. Prinzen,Liliane Wecke +6 more
TL;DR: QRSAREA was larger in echocardiographic responders than in non-responders and predicted CRT response better than QRS duration and than simple LBBB criteria, and is a promising electrophysiological predictor ofCRT response.
Journal ArticleDOI
Identification of responders to cardiac resynchronization therapy by contractile reserve during stress echocardiography.
TL;DR: The role of dyssynchrony (DYS) and contractile reserve (CR) in identifying CRT responders is assessed and the number of responders to cardiac resynchronization therapy (CRT) remains a challenge.
Journal ArticleDOI
Tissue Plasminogen Activator Antigen and D-Dimer as Markers for Atherothrombotic Risk Among Healthy Postmenopausal Women
Aruna D. Pradhan,Andrea Z. LaCroix,Robert Langer,Maurizio Trevisan,Cora E. Lewis,Judith Hsia,Albert Oberman,Jane Morley Kotchen,Paul M. Ridker +8 more
TL;DR: Elevated tPA antigen and, to a lesser extent, D-dimer are independently associated with incident coronary events among postmenopausal women.
Journal ArticleDOI
Assessment of Longitudinal and Radial Ventricular Dyssynchrony in Ischemic and Nonischemic Chronic Systolic Heart Failure: A Two-Dimensional Echocardiographic Speckle-Tracking Strain Study
Erwan Donal,Francois Tournoux,Christophe Leclercq,Christian de Place,Aude Solnon,Geneviève Derumeaux,Philippe Mabo,Alain Cohen-Solal,Jean-Claude Daubert +8 more
TL;DR: The new 2-dimensional speckle-tracking strain against color Doppler tissue imaging (DTI)-strain to compare the different correlation between electrical and mechanical dyssynchrony (DYS) in ischemic and nonischemic cardiomyopathies found to be correlated with QRS duration.
References
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Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
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Journal ArticleDOI
Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay
Serge Cazeau,Christophe Leclercq,Thomas Lavergne,S Walker,Varma C,Cecilia Linde,Stéphane Garrigue,Lukas Kappenberger,G A Haywood,Massimo Santini,Bailleul C,Jean-Claude Daubert,Multisite Stimulation in Cardiomyopathies (Mustic) Study Investigators +12 more
TL;DR: In this article, transvenous atriobiventricular pacemakers (with leads in one atrium and each ventricle) were used to reduce ventricular asynchrony.
Journal Article
The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure
Gordon H. Guyatt,Michael J. Sullivan,Penelope J. Thompson,Ernest L. Fallen,S. O. Pugsley,D W Taylor,Leslie B. Berman +6 more
TL;DR: It is concluded that the 6-minute walk is a useful measure of functional exercise capacity and a suitable measure of outcome for clinical trials in patients with chronic heart failure.
Journal ArticleDOI
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II
Bertram Pitt,Philip A. Poole-Wilson,Robert Segal,Felipe Martinez,Kenneth Dickstein,A. John Camm,Marvin A. Konstam,Günter A.J. Riegger,George Klinger,James D. Neaton,Divakar Sharma,Balasamy Thiyagarajan +11 more
TL;DR: The ELITE II Losartan Heart Failure Survival Study as discussed by the authors showed an association between the angiotensin II antagonist losartan and an unexpected survival benefit in elderly heart-failure patients, compared with captopril, an ACE inhibitor.